Decreased Connectivity in Precuneus of the Ventral Attentional Network in First-Episode, Treatment-Naive Patients With Major Depressive Disorder: A Network Homogeneity and Independent Component Analysis

Background and ObjectiveThe ventral attentional network (VAN) can provide quantitative information on cognitive problems in patients with major depressive disorder (MDD). Nevertheless, little is known about network homogeneity (NH) changes in the VAN of these patients. The aim of this study was to examine the NH values in the VAN by independent component analysis (ICA) and compare the NH values between MDD patients and the normal controls (NCs). MethodsAttentional network test and resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 73 patients, and 70 NCs matched by gender, age, and education years. ICA and NH were employed to evaluate the data. Moreover, the NH values were compared, and Spearman's rank correlation analysis was used to assess the correlations with the executive control reaction time (ECRT). ResultsOur results showed that the first-episode, treatment-naive MDD patients had decreased NH in the right precuneus (PCu) and abnormal ECRT compared with NCs. However, no significant correlation was found between the NH values and measured clinical variables. ConclusionOur results highlight the potential importance of VAN in the pathophysiology of cognitive problems in MDD, thus offering new directions for future research on MDD.

Automated summary

This study aimed to compare the network homogeneity (NH) values in the ventral attentional network (VAN) between patients with major depressive disorder (MDD) and normal controls (NCs). The results showed that treatment-naive MDD patients had decreased NH in the right precuneus (PCu) and abnormal executive control reaction time (ECRT). However, no significant correlation was found between the NH values and clinical variables.