Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.873286
Keywords
antinuclear antibodies (ANAs); recurrent pregnancy loss (RPL); prognostic value; pregnancy outcome; immunotherapy
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Funding
- Shenzhen Key Medical Discipline Construction Fund [SZXK028]
- Shenzhen Science and Technology Program [JCYJ20210324141403009]
- Basic and Applied Basic Research Foundation of Guangdong Province of China [2020A1515110082]
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This review assesses the association between ANAs and RPL, as well as the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL. It aims to provide a relevant reference basis for clinical application in this group of women.
In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. However, the relationship between the presence of ANAs and RPL, the underlying mechanism, and the possible role of immunotherapy is still controversial. The aim of this mini review is to assess the association between ANAs and RPL and the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL from the available data and to provide a relevant reference basis for clinical application in this group of women.
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