☆ 4.7 Article

Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

FRONTIERS IN ENDOCRINOLOGY (2022)

Related references

Note: Only part of the references are listed.

Review Cell Biology

The CD38 glycohydrolase and the NAD sink: implications for pathological conditions

Julianna D. Zeidler et al.

Summary: Nicotinamide adenine dinucleotide (NAD) plays a crucial role in cellular processes and its homeostasis is essential for health and disease. CD38 enzyme is a key regulator of NAD homeostasis and dysregulation of CD38 can contribute to various diseases.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

Add to Collection

Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Add to Collection

Review Cell Biology

Evolving concepts in NAD+ metabolism

Claudia C. S. Chini et al.

Summary: NAD and NADP have diverse roles beyond co-factors in oxidation-reduction reactions, including signaling pathways, post-translational modifications, epigenetic changes, and RNA regulation. Recent studies have shown that NAD metabolism is highly dynamic with a short halflife in some tissues, and new concepts are emerging in the roles of NAD pathway metabolites in various disease states. Resolving open questions in NAD biology will lead to significant advancements in the field.

CELL METABOLISM (2021)

Add to Collection

Review Cell Biology

Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad

Maria Eugenia Matzkin et al.

Summary: The male reproductive system undergoes aging primarily affecting the testes, resulting in decreased sexual hormone levels, altered sperm quality, and reduced fertility. Inflammation, oxidation, and apoptosis are predictors of aging-related diseases, with pro-inflammatory molecules and reactive oxygen species identified as contributing factors for testicular aging. The impact of age-related testicular changes on fertility, reproductive health, and lifespan remains incompletely understood, motivating research into anti-aging interventions and therapies utilizing pharmaceuticals or natural alternatives with anti-inflammatory, antioxidant, and anti-apoptotic properties.

CELLS (2021)

Add to Collection

Review Developmental Biology

Healthy ageing and spermatogenesis

Eva Pohl et al.

Summary: This passage discusses the impact of delayed family planning and increased parental age on infertility and offspring health. It highlights the challenges in assessing the effects of ageing on male germline, as well as the need to differentiate between ageing-associated morbidities, infertility, and 'pure' ageing. The review also presents current knowledge on healthy ageing and spermatogenesis, suggesting that healthy ageing may not necessarily affect testicular function negatively.

REPRODUCTION (2021)

Add to Collection

Article Cell Biology

The balance between NAD+ biosynthesis and consumption in ageing

Oyvind Stromland et al.

Summary: NAD(+) is an important coenzyme in redox reactions and cellular signaling, regulating essential processes like DNA repair, immune cell function, senescence, and chromatin remodeling. The decline of NAD(+) levels with age has been linked to various age-related diseases such as metabolic diseases and cognitive decline. Therapeutic augmentation of NAD(+) levels can halt or reverse the progression of age-related diseases.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Add to Collection

Review Andrology

Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesis

Rachel Gewiss et al.

ANDROLOGY (2020)

Add to Collection

Article Endocrinology & Metabolism

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Claudia C. S. Chini et al.

NATURE METABOLISM (2020)

Add to Collection

Article Andrology

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells

E. Pohl et al.

ANDROLOGY (2019)

Add to Collection

Article Obstetrics & Gynecology

Cytological and molecular aspects of the ageing sperm

Donatella Paoli et al.

HUMAN REPRODUCTION (2019)

Add to Collection

Review Cell Biology

NAD metabolism: Implications in aging and longevity

Keisuke Yaku et al.

AGEING RESEARCH REVIEWS (2018)

Add to Collection

Article Medicine, General & Internal

Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study

Yash S. Khandwala et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Add to Collection

Article Cell Biology

Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis

Laura Palzer et al.

CELL REPORTS (2018)

Add to Collection

Article Obstetrics & Gynecology

The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015

Yash S. Khandwala et al.

HUMAN REPRODUCTION (2017)

Add to Collection

Article Cell Biology

NAD and the aging process: Role in life, death and everything in between

Claudia C. S. Chini et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Add to Collection

Review Pharmacology & Pharmacy

Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor

Kristian Leisegang et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Add to Collection

Review Pharmacology & Pharmacy

Fertility and Sperm Quality in the Aging Male

Susana Almeida et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Add to Collection

Article Cell Biology

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Juliana Camacho-Pereira et al.

CELL METABOLISM (2016)

Add to Collection

Article Reproductive Biology

Male Rat Germ Cells Display Age-Dependent and Cell-Specific Susceptibility in Response to Oxidative Stress Challenges

Johanna Selvaratnam et al.

BIOLOGY OF REPRODUCTION (2015)

Add to Collection

Review Multidisciplinary Sciences

NAD+ in aging, metabolism, and neurodegeneration

Eric Verdin

SCIENCE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations

Samuel L. Arnold et al.

JOURNAL OF LIPID RESEARCH (2015)

Add to Collection

Review Cell Biology

NAD+ and sirtuins in aging and disease

Shin-ichiro Imai et al.

TRENDS IN CELL BIOLOGY (2014)

Add to Collection

Article Genetics & Heredity

Retinoic Acid Activates Two Pathways Required for Meiosis in Mice

Jana Koubova et al.

PLOS GENETICS (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes et al.

CELL (2013)

Add to Collection

Article Biochemistry & Molecular Biology

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Laurent Mouchiroud et al.

CELL (2013)

Add to Collection

Review Urology & Nephrology

Ageing of the male germ line

Catriona Paul et al.

NATURE REVIEWS UROLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males

Ming-Han Tong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Add to Collection

Article Multidisciplinary Sciences

Age Related Changes in NAD plus Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (Publication with Expression of Concern. See vol. 17, 2022)

Nady Braidy et al.

PLOS ONE (2011)

Add to Collection

Review Medicine, Research & Experimental

The key role of vitamin A in spermatogenesis

Cathryn A. Hogarth et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of intracellular levels of NAD: A novel role for CD38

Pinar Aksoy et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Add to Collection

Article Gastroenterology & Hepatology

Biochemical assessment of niacin deficiency among carcinoid cancer patients

GM Shah et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.