Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.853822
Keywords
ferroptosis; diabetes; diabetic complications; diabetic kidney disease; iron
Categories
Funding
- National Natural Science Foundation [81603171]
- Hunan Provincial Natural Scientific Foundation [2018JJ3743]
- Hunan Traditional Chinese Medicine Science and Technology Project [2021061]
Ask authors/readers for more resources
This review summarizes the role and regulatory mechanisms of ferroptosis in diabetes and its complications, as well as the inhibitors of ferroptosis in diabetes and diabetic complications. Understanding the regulation of ferroptosis and developing drugs targeting ferroptosis may provide new treatment strategies for patients with diabetes.
The global diabetes epidemic and its complications are increasing, thereby posing a major threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its complications is necessary for the development of effective treatments. Ferroptosis is a newly identified form of programmed cell death caused by the production of reactive oxygen species and an imbalance in iron homeostasis. Increasing evidence suggests that ferroptosis plays a pivotal role in the pathogenesis of diabetes and diabetes-related complications. In this review, we summarize the potential impact and regulatory mechanisms of ferroptosis on diabetes and its complications, as well as inhibitors of ferroptosis in diabetes and diabetic complications. Therefore, understanding the regulatory mechanisms of ferroptosis and developing drugs or agents that target ferroptosis may provide new treatment strategies for patients with diabetes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available