Journal
JOURNAL OF BIOTECHNOLOGY
Volume 222, Issue -, Pages 117-142Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2016.02.007
Keywords
Alkanes; Biohydroxylation; Biocatalysts; Bioreactors; Cofactor regeneration; Alcohol removal
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Alkanes constitute one of the vastest reserves of raw materials for the production of fine chemicals. This paper focuses on recent advances in alkane biohydroxylation, i.e. the bioactivation of alkanes into their corresponding alcohols. Enzyme and whole-cell biocatalysts have been reviewed. Process considerations to implement such biocatalysts in bioreactors at large scale by coupling the bioconversion with cofactor regeneration and product removal are also discussed. (c) 2016 Elsevier B.V. All rights reserved.
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