Journal
FRONTIERS IN GENETICS
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.877409
Keywords
essential miRNA; CART; XGBoost; sequence features; ensemble classifier
Categories
Funding
- National Natural Science Foundation of China [NSFC 61872268]
- National Key R&D Program of China [2018YFC0910405]
Ask authors/readers for more resources
This study proposed a method named XGEM to predict essential miRNAs using the XGBoost framework with CART. XGEM showed promising prediction performance compared to other state-of-the-art methods, suggesting its potential in identifying essential miRNAs.
MicroRNAs (miRNAs) play vital roles in gene expression regulations. Identification of essential miRNAs is of fundamental importance in understanding their cellular functions. Experimental methods for identifying essential miRNAs are always costly and time-consuming. Therefore, computational methods are considered as alternative approaches. Currently, only a handful of studies are focused on predicting essential miRNAs. In this work, we proposed to predict essential miRNAs using the XGBoost framework with CART (Classification and Regression Trees) on various types of sequence-based features. We named this method as XGEM (XGBoost for essential miRNAs). The prediction performance of XGEM is promising. In comparison with other state-of-the-art methods, XGEM performed the best, indicating its potential in identifying essential miRNAs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available