Applications of Non-Coding RNAs in Patients With Retinoblastoma

Retinoblastoma (RB) is the most common primary intraocular malignancy in childhood. In the carcinogenic process of neoplasms such as RB, the role of non-coding RNAs (ncRNAs) has been widely demonstrated recently. In this review, we aim to provide a clinical overview of the current knowledge regarding ncRNAs in relation to RB. Although ncRNAs are now considered as potential diagnostic biomarkers, prognostic factors, and therapeutic targets, further studies will facilitate enhanced understanding of ncRNAs in RB physiopathology and define the roles ncRNAs can play in clinical practice.

Automated summary

This review provides a clinical overview of the current knowledge on non-coding RNAs (ncRNAs) in relation to retinoblastoma (RB). It highlights the potential roles of ncRNAs as diagnostic biomarkers, prognostic factors, and therapeutic targets in RB. Further research is needed to enhance our understanding of ncRNAs in RB pathophysiology and define their roles in clinical practice.