Journal
FRONTIERS IN GENETICS
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.850114
Keywords
varicocele; oxidative stress; antioxidant; infertility; DNA oxidation damage
Categories
Funding
- Natural Science Foundation of Anhui Province (China) [2008085QC111]
- Key Research and Development Project of Anhui Province (China) [202104j07020016]
- Natural Science Foundation of the Higher Education Institutions of Anhui Province (China) [KJ2021A0704]
- Outstanding Young Talents Support Program in Colleges and Universities of Anhui Province (China) [gxyq2020021]
- 512 Talent Cultivation Plan of Middle-aged Backbone Teachers of Bengbu Medical College (China) [by51201207]
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According to WHO statistics, millions of couples and individuals suffer from infertility, with varicocele identified as a leading cause of male infertility. This review examines the role of oxidative stress and reactive oxygen species (ROS) in the pathophysiology of varicocele and its impact on fertility. High levels of ROS can lead to infertility by damaging DNA, affecting lipid peroxidation, and inactivating enzymes and proteins involved in spermatogenesis.
According to the official statistics of the World Health Organization, at least 48 million couples and 186 million people suffer from infertility. Varicocele has been recognized as the leading cause of male infertility and can affect spermatogenesis and cause testicular and epididymal disorders through multiple diverse pathophysiological processes. Reactive oxygen species (ROS) produced by oxidative stress have been reconciled as an important pathogenic factor throughout the course of varicocele. Testis respond to heat stress, hypoxia, and inflammation at the cost of producing excessive ROS. High levels of ROS can lead to infertility not only through lipid peroxidation or DNA damage, but also by inactivating enzymes and proteins in spermatogenesis. This review studies the oxidative stress and its role in the pathophysiology and molecular biology of varicocele in the context of a decline in fertility.
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