4.6 Article

Pyroptosis-Related lncRNAs Predict the Prognosis and Immune Response in Patients With Breast Cancer

Related references

Note: Only part of the references are listed.
Review Oncology

Pembrolizumab and atezolizumab in triple-negative breast cancer

Dorota Kwapisz

Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and limited treatment options, but it shows higher immunogenicity, tumor-infiltrating lymphocytes (TILs) enrichment, and programmed cell death ligand 1 (PD-L1) expression which make it more suitable for immune checkpoint blockade therapy. Patients with PD-L1-positive TNBC subgroup may benefit the most from immune checkpoint inhibitor (ICI) treatment, and ICI given as first-line treatment in advanced TNBC shows better results than in later lines of treatment. Exciting results have been seen with pembrolizumab in early-stage TNBC, indicating potential approval in (neo)adjuvant settings in the near future.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Chemistry, Multidisciplinary

A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis

Yilu Qin et al.

Summary: This study identified a novel lncRNA named lnc030 that plays a crucial role in BCSCs by stabilizing SQLE mRNA through interaction with PCBP2, leading to increased cholesterol synthesis and activation of the PI3K/Akt signaling pathway, which governs BCSC stemness.

ADVANCED SCIENCE (2021)

Review Biotechnology & Applied Microbiology

Channelling inflammation: gasdermins in physiology and disease

Xing Liu et al.

Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Oncology

Pyroptosis, a new bridge to tumor immunity

Lisha Li et al.

Summary: Pyroptosis is a type of programmed cell death that can activate the immune system to kill cancer cells, yet it may also promote tumor development by changing the immune microenvironment.

CANCER SCIENCE (2021)

Article Medicine, Research & Experimental

m6A-related lncRNAs are potential biomarkers for predicting prognoses and immune responses in patients with LUAD

Feng Xu et al.

Summary: This study established a risk model for predicting the prognosis and immunotherapeutic response of LUAD patients based on m(6)A-related lncRNAs, which can effectively distinguish patients and fit clinical predictions. The research also identified candidate compounds targeting LUAD subtypes.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Oncology

Pyroptosis in Cancer: Friend or Foe?

Xiuxia Lu et al.

Summary: Pyroptosis, a new form of programmed cell death, has garnered attention in cancer research. Various stimuli can trigger pyroptosis, but its role in cancer remains unclear with conflicting findings. Despite the uncertainties, pyroptosis may hold potential as a promising anti-cancer therapy.

CANCERS (2021)

Article Oncology

Identification of an m6A-Related lncRNA Signature for Predicting the Prognosis in Patients With Kidney Renal Clear Cell Carcinoma

JunJie Yu et al.

Summary: In this study, an m6A-related lncRNAs signature was constructed and validated using TCGA database to accurately predict the prognosis of KIRC patients. The high-risk subgroup showed significantly poorer survival rates than the low-risk subgroup, with reliable predictive capabilities of the prognostic signature in the training set (AUC = 0.802) and testing set (AUC = 0.725). A prognostic nomogram with high C-index and good prediction accuracy was established, along with insights from lncRNA/miRNA/mRNA ceRNA network, PPI network, and functional enrichment analysis for potential biological functions.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Cell Biology

CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling

Fang Wang et al.

Summary: circNOL10 is down-regulated in breast cancer tissues and cells, and its low expression is associated with tumor size, TNM stage, lymph node metastasis, and poor prognosis. It acts as a sponge for miR-767-5p to up-regulate SOCS2 and inactivate the JAK2/STAT5 pathway, thereby repressing breast cancer development.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

Article Biochemistry & Molecular Biology

Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma

Yun Tang et al.

Summary: In this study, a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC was constructed and found to impact the prognosis of HNSCC, outperforming traditional clinicopathological features in predicting HNSCC prognosis. The signature was associated with poor prognosis of HNSCC, with a higher AUC value. GSEA identified immune and tumor-related pathways affected by the signature, while TCGA revealed significant differences in T cell functions and immune checkpoint expression between low-risk and high-risk groups.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Oncology

Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature

Saranya Chumsri et al.

Journal of the National Comprehensive Cancer Network (2020)

Article Biochemistry & Molecular Biology

Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathway

Zijin Xiang et al.

BIOSCIENCE REPORTS (2020)

Article Multidisciplinary Sciences

Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer

Ning Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome

Yeon Hee Park et al.

NATURE COMMUNICATIONS (2020)

Article Oncology

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

Ji Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

Activation of Pyroptotic Cell Death Pathways in Cancer: Alternative Therapeutic approach

Kanipandian Nagarajan et al.

TRANSLATIONAL ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection

Cheng-Bei Zhou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Review Medicine, Research & Experimental

Inflammasome as a promising therapeutic target for cancer

Chaelin Lee et al.

LIFE SCIENCES (2019)

Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

Article Biochemistry & Molecular Biology

LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription

Bingqiu Xiu et al.

MOLECULAR CANCER (2019)

Review Biochemistry & Molecular Biology

Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches

Xingyang Qian et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Multidisciplinary Sciences

An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment

Xavier Tekpli et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

Long Noncoding RNA in Cancer: Wiring Signaling Circuitry

Chunru Lin et al.

TRENDS IN CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

PAN-cancer analysis of S-phase enriched IncRNAs identifies oncogenic drivers and biomarkers

Mohamad Moustafa Ali et al.

NATURE COMMUNICATIONS (2018)

Article Clinical Neurology

Prospective Series of Nine Long Noncoding RNAs Associated with Survival of Patients with Glioblastoma

Bingxi Lei et al.

JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY (2018)

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Article Oncology

Breast Cancer: Multiple Subtypes within a Tumor?

Syn Kok Yeo et al.

TRENDS IN CANCER (2017)

Article Oncology

Drawing Nomograms with R: applications to categorical outcome and survival data

Zhongheng Zhang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2017)

Editorial Material Biochemistry & Molecular Biology

Pyroptosis

Lieselotte Vande Walle et al.

CURRENT BIOLOGY (2016)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

Review Genetics & Heredity

Long non-coding RNAs: new players in cell differentiation and development

Alessandro Fatica et al.

NATURE REVIEWS GENETICS (2014)

Article Genetics & Heredity

Imprinted Chromatin around DIRAS3 Regulates Alternative Splicing of GNG12-AS1, a Long Noncoding RNA

Malwina Niemczyk et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2013)

Article Multidisciplinary Sciences

Inferring tumour purity and stromal and immune cell admixture from expression data

Kosuke Yoshihara et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)