4.6 Article

Necroptosis-Related miRNA Biomarkers for Predicting Overall Survival Outcomes for Endometrial Cancer

Related references

Note: Only part of the references are listed.
Article Cell Biology

FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC

Dhrutiy Patel et al.

Summary: HNSCC is the sixth most common malignancy globally, with etiology including factors like tobacco, alcohol, and human papillomavirus infection. Analysis of independent gene expression datasets revealed that overexpression of ATG12, HSP90AB1, and FKBP1A is associated with poor prognosis in HNSCC, while overexpression of ANXA1, FOS, and ULK3 is associated with improved prognosis.

CELL BIOLOGY INTERNATIONAL (2022)

Article Oncology

Development and Validation of a Necroptosis-Related Prognostic Model in Head and Neck Squamous Cell Carcinoma

Zhijing Zhang et al.

Summary: In this study, a risk model of necroptosis-related genes was constructed to predict the overall survival time of patients with head and neck squamous cell carcinoma (HNSCC). The model showed promising predictive ability and could potentially serve as a new target for clinical diagnosis and treatment.

JOURNAL OF ONCOLOGY (2022)

Article Medical Laboratory Technology

Necroptosis-related lncRNA to establish novel prognostic signature and predict the immunotherapy response in breast cancer

Fangyue Chen et al.

Summary: This study investigates the immune landscape in breast cancer by screening necroptosis-related long non-coding RNAs (lncRNAs). The results show that these lncRNAs are related to immune-related pathways and that the risk score is significantly correlated with immune cell infiltration and ESTIMATE score. Furthermore, patients with higher risk scores show better immune checkpoint blockade response.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

Article Biochemistry & Molecular Biology

Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

Piotr Januszyk et al.

Summary: The study showed that salinomycin treatment resulted in changes in gene expression in Ishikawa endometrial cancer cells related to drug resistance, with corresponding effects on miRNA levels. Specific genes (such as TUFT1, MTMR11, SLC30A5) exhibited significant changes in expression, with strong associations observed with certain miRNAs.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2021)

Review Cell Biology

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

Yan Liu et al.

Summary: This review summarizes the role of necroptosis, pyroptosis, and ferroptosis in cancer metastasis, as well as how non-coding RNAs precisely regulate programmed death and tumor metastasis in the process of tumor metastasis.

CELL DEATH DISCOVERY (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Biochemistry & Molecular Biology

Expression Profile of EMT-related Genes and miRNAs Involved in Signal Transduction via the Wnt Pathway and Cadherins in Endometrial Cancer

Nikola Zmarzly et al.

Summary: This study investigated the expression profile of EMT-related genes and miRNAs in endometrial cancer samples. The disruption of Wnt signaling in endometrial cancer may be attributed to the activity of miR-331-3p and miR-200b-5p. Furthermore, the altered expression of WNT5A in endometrial cancer may indicate its role as a tumor suppressor gene associated with tumor progression.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Proteomic Analysis of Low-Grade, Early-Stage Endometrial Carcinoma Reveals New Dysregulated Pathways Associated with Cell Death and Cell Signaling

Alvaro Lopez-Janeiro et al.

Summary: The study investigated dysregulated molecular pathways in low-grade, early-stage endometrial carcinoma (EC) through proteomic analysis. The SLIT/ROBO signaling pathway, necroptosis, and ferroptosis were found to be dysregulated, along with immune-related pathways dominated by innate immune responses. These findings could provide guidance for future research in this subset of tumors.

CANCERS (2021)

Article Toxicology

Long non-coding RNA Down syndrome cell adhesion molecule-anti-sense 1 promotes gastric carcinoma cell proliferation and migration by regulating the miR-204/TPT1 axis

Nan Wang et al.

Summary: The study revealed the overexpression of DSCAM-AS1 in gastric carcinoma, with its silencing resulting in reduced proliferation and migration of GC cells. MiR-204 was identified as a target of DSCAM-AS1, which in turn targeted TPT1 in GC cells. These findings suggest the potential of DSCAM-AS1 as a therapeutic target for preventing GC progression.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Article Oncology

Diagnostic potential of differentially regulated microRNAs among endometriosis, endometrioid ovarian cancer, and endometrial cancer

Priti Kumari et al.

Summary: The study found that miR-99b and miR-125a have high diagnostic potential for endometriosis, miR-143 plays an important role in predicting endometrioid ovarian cancer, and miR-16, miR-99b, and miR-145 are the best predictors for endometrial cancer. These miRNAs could act as good predictors and discriminators of these three diseases, potentially serving as biomarkers for them.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2021)

Article Cell Biology

CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

Haineng Xu et al.

Summary: Ovarian and endometrial cancers with CCNE1 amplification are associated with platinum resistance and poor survival outcomes. Targeting dysregulated cell cycle progression with low-dose WEE1 inhibition and ATR inhibition synergistically decreases cell viability and increases DNA damage, providing a potential therapeutic strategy for these aggressive subsets of cancers.

CELL REPORTS MEDICINE (2021)

Review Biochemistry & Molecular Biology

Necroptosis and its role in infectious diseases

Xiaojing Xia et al.

APOPTOSIS (2020)

Article Cell Biology

Novel miRNA markers for the diagnosis and prognosis of endometrial cancer

Qian Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

PtenandDicer1loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma

Xiyin Wang et al.

ONCOGENE (2020)

Article Biochemistry & Molecular Biology

MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133

Jian Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Coming Decade of Cell Death Research: Five Riddles

Douglas R. Green

Review Biochemistry & Molecular Biology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Daniel Frank et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Medicine, Research & Experimental

Necroptosis: a crucial pathogenic mediator of human disease

Mary E. Choi et al.

JCI INSIGHT (2019)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Oncology

Management Strategies for Recurrent Endometrial Cancer

Elizabeth V. Connor et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2018)

Article Obstetrics & Gynecology

Expression Profiles of Endometrial Carcinoma by Integrative Analysis of TCGA Data

Huizhen Sun et al.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2017)

Review Multidisciplinary Sciences

Programmed necrosis in inflammation: Toward identification of the effector molecules

David Wallach et al.

SCIENCE (2016)

Review Biochemistry & Molecular Biology

Apoptosis, autophagy, necroptosis, and cancer metastasis

Zhenyi Su et al.

MOLECULAR CANCER (2015)

Review Multidisciplinary Sciences

Necroptosis and its role in inflammation

Manolis Pasparakis et al.

NATURE (2015)

Article Genetics & Heredity

The role of miRNAs in endometrial cancer

Diamantina Vasilatou et al.

EPIGENOMICS (2015)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Cell Biology

Necroptosis as an alternative form of programmed cell death

Dana E. Christofferson et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Review Genetics & Heredity

Role of epigenomics in ovarian and endometrial cancers

Curtis Balch et al.

EPIGENOMICS (2010)

Editorial Material Biochemistry & Molecular Biology

Necroptosis: A Specialized Pathway of Programmed Necrosis

Lorenzo Galluzzi et al.

Article Cell Biology

Control of cell proliferation pathways by microRNAs

Maria Jose Bueno et al.

CELL CYCLE (2008)