Comprehensive Analysis of the Correlation Between Pyroptosis-Related LncRNAs and Tumor Microenvironment, Prognosis, and Immune Infiltration in Hepatocellular Carcinoma

Article Multidisciplinary Sciences

Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer

Zaoqu Liu et al.

Summary: The study developed a machine learning-based method to predict prognosis, recurrence, and treatment benefits in colorectal cancer patients, and constructed an immune-related long non-coding RNA signature.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Stemness Refines the Classification of Colorectal Cancer With Stratified Prognosis, Multi-Omics Landscape, Potential Mechanisms, and Treatment Options

Zaoqu Liu et al.

Summary: This study deciphers two stemness clusters in colorectal cancer (CRC), which have stratified prognosis, multi-omics landscape, potential mechanisms, and treatment options. It provides new insights into the heterogeneity of cancer stemness and sheds light on optimizing decision-making in immunotherapy and chemotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cell Biology

Immune Landscape Refines the Classification of Colorectal Cancer With Heterogeneous Prognosis, Tumor Microenvironment and Distinct Sensitivity to Frontline Therapies

Zaoqu Liu et al.

Summary: By conducting consensus clustering of immune-related gene expression profiles, this study identified two immune subtypes in CRC and characterized their immune features, gene alterations, and clinical manifestations. The two subtypes showed differences in immune escape mechanisms, prognosis, and treatment sensitivity. Furthermore, a prognosis associated risk score (PARS) and two nomograms for predicting overall survival and disease-free survival were developed to assist clinical management.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection

Article Pathology

Clinicopathological significance of CD47 expression in hepatocellular carcinoma

Hyunsung Kim et al.

Summary: CD47 expression is significantly associated with adverse pathological features and poor clinical outcomes in patients with HCC.

JOURNAL OF CLINICAL PATHOLOGY (2021)

Add to Collection

Article Cell Biology

Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma

Kuan Hu et al.

Aging-US (2021)

Add to Collection

Article Immunology

A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma

Wenying Zhu et al.

Summary: This study identified a potential clinical value of pyroptosis-related long non-coding RNAs in head and neck squamous cell carcinoma. The lncRNA signature consisting of 14 pyroptosis-related long non-coding RNAs could serve as a prognostic marker for HNSCC, suggesting pyroptosis as a promising therapeutic target in this type of cancer.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Add to Collection

Article Immunology

Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer

JianBin Wu et al.

Summary: This study revealed the crucial role of pyroptosis in breast cancer, showing its association with tumor progression, prognosis, and immunotherapy response. Evaluating the PyroptosisScore of a single tumor can help understand the characteristics of tumor microenvironment infiltration and lead to the development of more effective immunotherapy strategies.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Genetics & Heredity

Identification of a Ferroptosis-Related Long Noncoding RNA Prognostic Signature and Its Predictive Ability to Immunotherapy in Hepatocellular Carcinoma

Liang Wang et al.

Summary: The study identified a ferroptosis-related lncRNA signature that accurately predicts the overall survival of HCC patients and may serve as an independent clinical factor for patients' outcomes. These lncRNAs may remodel the tumor microenvironment (TME) and affect the anti-cancer ability of ICBs, potentially acting as an indicator for the response to immunotherapy in HCC.

FRONTIERS IN GENETICS (2021)

Add to Collection

Article Genetics & Heredity

Identification and Validation of Hypoxia-Related lncRNA Signature as a Prognostic Model for Hepatocellular Carcinoma

Chenghui Zhou et al.

Summary: This study established a signature based on hypoxia-related lncRNAs to predict the survival of HCC patients. The low-risk group showed better survival outcomes and was associated with clinical features, immune cell infiltration, and m6A-related genes.

FRONTIERS IN GENETICS (2021)

Add to Collection

Article Oncology

A Novel Pyroptosis-Related lncRNAs Signature for Predicting the Prognosis of Kidney Renal Clear Cell Carcinoma and Its Associations with Immunity

Xinfang Tang et al.

Summary: This research identified a predictive multi-lncRNA signature related to poor prognosis in clear cell renal cell carcinoma (ccRCC) through studying pyroptosis-related differentially expressed lncRNAs. The developed 14-lncRNA predictor showed superior performance in predicting ccRCC prognosis compared to standard clinicopathological characteristics. Additionally, immune checkpoint expressions and tumor-related pathways were found to be different between high-risk and low-risk groups in ccRCC patients, indicating potential implications for therapeutic strategies.

JOURNAL OF ONCOLOGY (2021)

Add to Collection

Article Oncology

Computational Recognition and Clinical Verification of TGF-β-Derived miRNA Signature With Potential Implications in Prognosis and Immunotherapy of Intrahepatic Cholangiocarcinoma

Zaoqu Liu et al.

Summary: This study identified 36 TGF-beta-derived miRNAs, of which 9 were significantly correlated with overall survival in ICC patients. A TGF-beta associated miRNA signature (TAMIS) was discovered and validated, proving to be an independent risk indicator for both OS and RFS in ICC. TAMIS showed robust performance in three cohorts and provided important insights for immunotherapies of ICC patients.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Cell Biology

Systematic Construction and Validation of a Prognostic Model for Hepatocellular Carcinoma Based on Immune-Related Genes

Jiahao Yu et al.

Summary: This study established an effective model for predicting the prognosis of HCC patients based on immune-related genes and validated the model's reliability. The specific immune-related genes identified were not only associated with the prognosis of liver cancer, but also correlated with the tumor immune microenvironment, clinical stage, and sensitivity to anti-cancer drugs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Hepatocellular Carcinoma

Xiaofei Feng et al.

Summary: The study focuses on constructing a prognostic signature using immune-related gene pairs (IRGPs) to assess overall survival in patients with Hepatocellular carcinoma (HCC). The signature not only provides insights into the immune checkpoint therapy responsiveness and drug sensitivity, but also offers new strategies for personalized management and treatment of the disease.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Add to Collection

Article Oncology

Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy

Jing Su et al.

Summary: This study used a multi-omics approach to characterize brain metastasis and identified two molecular subtypes with significantly different prognoses, revealing key pathways and metabolites. The results indicated that the immune microenvironment landscape and proliferation and migration signaling pathways may contribute to the observed survival differences, providing an opportunity to identify clinically impactful biomarkers.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Cell Biology

A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Ying Ye et al.

Summary: This study identified pyroptosis-related genes in ovarian cancer (OC) that may play important roles in tumor immunity and can be used to predict the prognosis of OCs. By dividing OC cases into subtypes based on the expression of these genes, different risk groups were identified with significant differences in survival possibilities. Additionally, immune-related genes were found to be enriched in high-risk groups, indicating a decreased immune status in these patients.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Cell Biology

Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Zetian Shen et al.

Aging-US (2021)

Add to Collection

Article Oncology

Identification of an m6A-Related lncRNA Signature for Predicting the Prognosis in Patients With Kidney Renal Clear Cell Carcinoma

JunJie Yu et al.

Summary: In this study, an m6A-related lncRNAs signature was constructed and validated using TCGA database to accurately predict the prognosis of KIRC patients. The high-risk subgroup showed significantly poorer survival rates than the low-risk subgroup, with reliable predictive capabilities of the prognostic signature in the training set (AUC = 0.802) and testing set (AUC = 0.725). A prognostic nomogram with high C-index and good prediction accuracy was established, along with insights from lncRNA/miRNA/mRNA ceRNA network, PPI network, and functional enrichment analysis for potential biological functions.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Cell Biology