4.6 Review

Research Advances on Matrine

Related references

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Article Biochemistry & Molecular Biology

Potential mechanism underlying the effect of matrine on COVID-19 patients revealed through network pharmacological approaches and molecular docking analysis

Wenpan Peng et al.

Summary: Through the research on matrine, it was found that matrine regulates viral replication, host cell apoptosis, and inflammation during COVID-19 treatment. The study revealed signaling pathways related to cell proliferation, apoptosis, programmed cell death, and immune response.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

Article Plant Sciences

Research progress of matrine's anticancer activity and its molecular mechanism

Fengyuan Chen et al.

Summary: Matrine, a traditional Chinese medicine alkaloid, has been shown to have multiple pharmacological effects, including anti-tumor, anti-inflammatory, and anti-viral properties. Research has demonstrated that matrine can promote cell apoptosis, inhibit tumor growth, and has significant potential for cancer treatment and prognosis.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Chemistry, Multidisciplinary

Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice

Xin Zhang et al.

Summary: Matrine attenuates cardiac fibrosis by regulating RPS5/p38 signaling, showing promising potential as a therapeutic agent for treating pathological cardiac fibrosis.

ACTA PHARMACOLOGICA SINICA (2021)

Article Biochemistry & Molecular Biology

Matrine attenuates cardiomyocyte ischemia-reperfusion injury through activating AMPK/Sirt3 signaling pathway

Qiubei Lu et al.

Summary: Matrine demonstrates a cardioprotective effect on cardiomyocyte damage under hypoxia/reoxygenation by upregulating Sirt3 and AMPK expression and activity. Inhibition of the Sirt3/AMPK pathway abolishes this protective action, leading to reduced cardiomyocyte viability and increased cell death. This study suggests a potential therapeutic application of matrine in treating patients with myocardial infarction.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2021)

Article Biochemistry & Molecular Biology

Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity

Yilei Jing et al.

Summary: In this study, it was found that treatment with matrine (MAT) inhibited the generation of neurotoxic A1 astrocytes and promoted the formation of neuroprotective A2 astrocytes in the CNS of EAE, primarily by inhibiting the production of cytokines that induce A1 cells. Additionally, MAT protected the BBB from damage caused by CNS inflammation and promoted astrocyte tight junction formation at the glia limitans, limiting immune cell invasion into the CNS parenchyma.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

Article Pharmacology & Pharmacy

Synergistic interaction between matrine and paracetamol in the acetic acid writhing test in mice

Guidong Dai et al.

Summary: The combination of matrine with paracetamol exerts analgesic synergistic interactions in a mouse acetic acid-induced writhing model, providing a possible therapeutic alternative for the clinical management of inflammatory pain.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Immunology

Modulation of the HMGB1/TLR4/NF-κB signaling pathway in the CNS by matrine in experimental autoimmune encephalomyelitis

Yaojuan Chu et al.

Summary: The study showed that MAT treatment alleviated disease severity and reduced inflammatory infiltration and demyelination in EAE rats by modulating the HMGB1/TLR4/NF-κB signaling pathway.

JOURNAL OF NEUROIMMUNOLOGY (2021)

Article Plant Sciences

In vitro and in vivo anti-metastatic effect of the alkaliod matrine from Sophora flavecens on hepatocellular carcinoma and its mechanisms

Meiqin Dai et al.

Summary: Matrine exhibits a significant anti-metastatic effect on HCC, attributed to enhanced miR-199a-5p expression and subsequently impaired HIF-1 alpha signaling and EMT. MiR-199a-5p may be a potential therapeutic target of HCC, and Matrine may represent a promising anti-metastatic medication for HCC therapy.

PHYTOMEDICINE (2021)

Article Multidisciplinary Sciences

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Jian Kang et al.

Summary: The study demonstrates that MAT has a significant therapeutic effect on inflammation, demyelination, and axonal loss in the optic nerve, and can protect RGCs from inflammation-induced cell death. MAT may be a potential treatment to prevent blindness caused by this disease.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Matrine suppression of self-renewal was dependent on regulation of LIN28A/Let-7 pathway in breast cancer stem cells

Xiang Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Article Medicine, Research & Experimental

Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition

Lili Ren et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Review Integrative & Complementary Medicine

Research Progress on Anti-Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

Sicong Li et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

Critical roles of inflammation in atherosclerosis

Junji Moriya

JOURNAL OF CARDIOLOGY (2019)

Article Biochemistry & Molecular Biology

Evans Blue Reduces Neuropathic Pain Behavior by Inhibiting Spinal ATP Release

Yuhua Yin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Pharmacology & Pharmacy

Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2

Guibin Lin et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Matrine pre-treatment suppresses AGEs- induced HCSMCs fibrotic responses by regulating Poldip2/mTOR pathway

Wangxia Ma et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Matrine suppresses AGE-induced HAEC injury by inhibiting ROS-mediated NRLP3 inflammasome activation

Yong Zhang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway

Bing-Gang Zhou et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Cell Biology

Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells

Junqing Wu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Article Pharmacology & Pharmacy

Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy

Zhongwei Liu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Agriculture, Multidisciplinary

Various Bioactivity and Relationship of Structure-Activity of Matrine Analogues

Wanjun Ni et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Article Chemistry, Medicinal

Evolution of matrinic ethanol derivatives as anti-HCV agents from matrine skeleton

Ying-Hong Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Medicinal

Novel 12N-substituted matrinanes as potential anti-coxsackievirus agents

Ying-Hong Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Biochemistry & Molecular Biology

Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

Daqing Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Chemistry, Medicinal

Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents

Lichuan Wu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Biochemistry & Molecular Biology

Matrine Exerts a Strong Anti-Arthritic Effect on Type II Collagen-Induced Arthritis in Rats by Inhibiting Inflammatory Responses

Jiang Pu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Medicine, Research & Experimental

Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice

Peng Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

Article Biotechnology & Applied Microbiology

Matrine reduces yeast-to-hypha transition and resistance of a fluconazole-resistant strain of Candida albicans

J. Shao et al.

JOURNAL OF APPLIED MICROBIOLOGY (2014)

Article Cell Biology

Matrine Inhibits Breast Cancer Growth Via miR-21/PTEN/Akt Pathway in MCF-7 Cells

Lin-Qiang Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Antiviral Effect of Matrine against Human Enterovirus 71

Yajun Yang et al.

MOLECULES (2012)

Article Cardiac & Cardiovascular Systems

EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1

Jin-Yi Tsai et al.

CARDIOVASCULAR RESEARCH (2010)

Article Environmental Sciences

Relaxant Effects of Matrine on Aortic Smooth Muscles of Guinea Pigs

Jie Zheng et al.

BIOMEDICAL AND ENVIRONMENTAL SCIENCES (2009)

Article Cardiac & Cardiovascular Systems

Changes in Connexin Expression and the Atrial Fibrillation Substrate in Congestive Heart Failure

Brett Burstein et al.

CIRCULATION RESEARCH (2009)