Journal
FRONTIERS IN CHEMISTRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.903253
Keywords
dicyanomethylene-4H-pyran (DCM); intramolecular charge transfer; near-infrared probe; bioimaging; biosensor
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Funding
- National Key R&D Program of China [2021ZD0201004]
- National Natural Science Foundation of China [22165008, 22077037]
- Hainan Provincial Natural Science Foundation of China [521RC506]
- Open Project Program of Wuhan National Laboratory for Optoelectronics [2020WNLOKF018]
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This article summarizes the recent applications of near-infrared DCM probes based on the ICT effect in biosensors and biological imaging. By regulating the ICT process, these probes can specifically act on target molecules.
As one of the typical fluorescent cores, dicyanomethylene-4H-pyran (DCM) derivatives exhibit excellent photophysical and photochemical properties, such as large Stokes shift, excellent light stability, and tunable near-infrared (NIR) emission. The luminescence mechanism of DCM probes mainly depends on the intramolecular charge transfer (ICT). Hence, by regulating the ICT process, the probes can specifically act on the target molecule. Accordingly, a series of NIR DCM probes have been constructed to detect the ions, reactive oxygen species (ROS), and biological macromolecules in cells. However, there is no relevant review to summarize it at present. This minireview mainly summarizes the NIR DCM probes based on ICT effect and their applications in biosensors and biological imaging in recent years. This will be beneficial to innovatively construct new DCM probes and actively promote their application in the future.
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