4.6 Review

Hypothalamic syndrome

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Hypothalamic inflammation in metabolic disorders and aging

Anup Bhusal et al.

Summary: The hypothalamus is a critical brain region for energy homeostasis regulation, with recent studies highlighting the role of glial cells in addition to neurons. However, inflammatory activation of these cells under metabolic stress conditions contributes to various metabolic diseases, worsening the disease state.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Endocrinology & Metabolism

Energy balance in hypothalamic obesity in response to treatment with a once-weekly GLP-1 receptor agonist

Ashley H. Shoemaker et al.

Summary: Treatment with a GLP1RA can decrease food intake but also lead to a disproportionate decrease in total energy expenditure compared to changes in body composition.

INTERNATIONAL JOURNAL OF OBESITY (2022)

Article Oncology

Radiotherapy alone for pediatric patients with craniopharyngioma

Michael Young et al.

Summary: Radiotherapy alone can be a suitable treatment option for patients with craniopharyngioma, providing excellent disease control and functional outcomes in appropriately selected patients where surgical intervention is not necessary.

JOURNAL OF NEURO-ONCOLOGY (2022)

Editorial Material Endocrinology & Metabolism

Bariatric Interventions in Craniopharyngioma Patients-Best Choice or Last Option for Treatment of Hypothalamic Obesity?

Hermann L. Mueller

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Article Endocrinology & Metabolism

A phase 3 randomized clinical trial using a once-weekly glucagon-like peptide-1 receptor agonist in adolescents and young adults with hypothalamic obesity

Christian L. Roth et al.

Summary: The study aimed to evaluate the efficacy and safety of GLP-1 RA in patients with HO. Although ExQW did not significantly change BMI after 36 weeks, it showed significant reductions in total body fat mass and waist circumference compared to placebo. GLP-1 RAs are a promising and safe treatment for improving or stabilizing HO in children and young adults.

DIABETES OBESITY & METABOLISM (2021)

Article Pediatrics

Prader-Willi Syndrome in children: Quality of life and caregiver burden

Christina Meade et al.

Summary: Prader-Willi syndrome significantly impacts the quality of life for both the affected child and the family, with increased weight and age affecting family functioning and relationships, as well as the child's psychosocial health and social functioning. Caregivers of children over 12 years old reported increased burden of care due to disruption of routines, restriction of social activities, and psychological difficulties.

ACTA PAEDIATRICA (2021)

Article Endocrinology & Metabolism

Oxytocin in young children with Prader-Willi syndrome: Results of a randomized, double-blind, placebo-controlled, crossover trial investigating 3 months of oxytocin

Layla Damen et al.

Summary: The study on the effects of intranasal oxytocin treatment on children with Prader-Willi syndrome showed positive effects on social and eating behavior, especially in boys aged 3-11 years and in children with a deletion, with no safety concerns. However, individual effects should be carefully evaluated.

CLINICAL ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

The use of growth hormone therapy in adults with Prader-Willi syndrome: A systematic review

Mikaela Frixou et al.

Summary: The role of growth hormone in adults with Prader-Willi syndrome remains unclear, with mixed effects on body composition, bone health, and cardiovascular health. While GH therapy appears safe and well-tolerated, further longitudinal studies are needed to explore its effects on bone and cardiovascular health.

CLINICAL ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Oxytocin Administration Increases Proactive Control in Men with Overweight or Obesity: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Franziska Plessow et al.

Summary: The study explores the potential of oxytocin to improve cognitive control over behavior in humans. Findings suggest that oxytocin enhances proactive control over behavior by improving the ability to suppress behavioral impulses, which may have implications for its anorexigenic effects in human obesity. Future research is needed to further investigate the impact of oxytocin on cognitive control and its role in weight loss treatment.

OBESITY (2021)

Article Oncology

Limited Surgery and Conformal Photon Radiation Therapy for Pediatric Craniopharyngioma: Long-Term Results From the RT1 Protocol

D. Edmonston et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Article Endocrinology & Metabolism

MRI measures of hypothalamic injury are associated with glucagon-like peptide-1 receptor agonist treatment response in people with hypothalamic obesity

Francisco A. Perez et al.

Summary: The study found that greater hypothalamic damage, especially involving the mammillary body (MB), is associated with greater reductions in adiposity in patients with hypothalamic obesity who received treatment with GLP-1RA.

DIABETES OBESITY & METABOLISM (2021)

Review Biochemistry & Molecular Biology

Prader-Willi Syndrome and Hypogonadism: A Review Article

Cees Noordam et al.

Summary: Prader-Labhart-Willi syndrome (PWS) is a rare genetic disorder characterized by features such as intellectual disability, behavioral problems, hypothalamic dysfunction, and specific dysmorphisms. Hypogonadism is prevalent in both males and females with PWS, but limited knowledge exists about this condition. This review outlines the current understanding of hypogonadism in PWS, including clinical, biochemical, genetic, and histological features, as well as treatment options and expert recommendations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Proton Radiation Therapy for Pediatric Craniopharyngioma

Rachel B. Jimenez et al.

Summary: This study reported clinical outcomes for a large cohort of pediatric craniopharyngioma patients treated with surgery and proton therapy. The results showed excellent disease control, rare severe acute toxicity, but prevalent late toxicities. Endocrine and ophthalmology follow-up is necessary, and neuropsychological testing may identify patients at risk for treatment-related cognitive and adaptive functioning changes.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Letter Genetics & Heredity

Time for a general approval of growth hormone treatment in adults with Prader-Willi syndrome

Charlotte Hoeybye et al.

Summary: Prader-Willi syndrome is a complex neurodevelopmental disorder characterized by a range of physical and intellectual disabilities. Growth hormone treatment has been shown to have positive effects on body composition, normalizing height, and improving quality of life in both children and adults with PWS. There is a need for international approval of GH treatment for adults with genetically confirmed PWS.

ORPHANET JOURNAL OF RARE DISEASES (2021)

Article Endocrinology & Metabolism

Descriptive epidemiology of craniopharyngiomas in the United States

Arbaz A. Momin et al.

Summary: This study utilized data from the Central Brain Tumor Registry of the United States to analyze the epidemiology of craniopharyngiomas from 2004 to 2016. The results showed that craniopharyngiomas are rare tumors with a bimodal age distribution and equal male-to-female incidence. Incidence was highest among Black patients and there was an age discrepancy in the distribution of different craniopharyngioma subtypes.

PITUITARY (2021)

Review Endocrinology & Metabolism

Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction

Maithe Tauber et al.

Summary: Prader-Willi syndrome is a rare genetic neurodevelopmental disorder characterized by impaired hypothalamic development and function, leading to a range of phenotypes from anorexia to obesity. Endocrine dysfunctions, including growth hormone deficiency and hormonal imbalances, are commonly observed in patients with this syndrome, requiring hormone replacement therapy for management.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Review Pediatrics

Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome

Laura Bosch i Ara et al.

Summary: Congenital hypopituitarism (CH) is a disorder characterized by deficiency in one or more pituitary hormones. The incidence is 1 in 4,000 to 1 in 10,000, with the majority of cases being sporadic. CH pathogenesis involves mutations in various genes such as HESX1, PROP1, and POU1F1. Clinical manifestations range from severe midline developmental disorders to isolated hormone deficiencies.

FRONTIERS IN PEDIATRICS (2021)

Review Biochemistry & Molecular Biology

A Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research

Delf-Magnus Kummerfeld et al.

Summary: PWS is a neurogenetic disorder caused by the deletion of paternally imprinted genes on chromosome 15q11-q13, with mouse models playing a crucial role in understanding the syndrome's pathogenesis. Through murine models, the contribution of each affected gene to PWS has been unveiled, shedding light on the importance of non-protein coding genes in the locus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, General & Internal

Hypogonadism in Women with Prader-Willi Syndrome-Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion

Karlijn Pellikaan et al.

Summary: Prader-Willi syndrome (PWS) is a rare neuroendocrine genetic syndrome characterized by hyperphagia, hypotonia, and intellectual disability. Females with PWS frequently experience hypogonadism, yet it is often undiagnosed and untreated. Timely detection and treatment of hypogonadism in females with PWS is crucial to prevent osteoporosis and other complications.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Endocrinology & Metabolism

Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome

Felipe Correa-da-Silva et al.

Summary: Prader-Willi Syndrome (PWS) is a rare and incurable congenital neurodevelopmental disorder characterized by hypotonia, short stature, hyperphagia, and morbid obesity. Research indicates that PWS patients have hypothalamic dysfunction, potentially impacting the pathophysiology of the syndrome.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

Article Psychiatry

Intranasal oxytocin versus placebo for hyperphagia and repetitive behaviors in children with Prader-Willi Syndrome: A randomized controlled pilot trial

Eric Hollander et al.

Summary: In children and adolescents with Prader Willi Syndrome, placebo showed modest improvement in hyperphagia and repetitive behaviors, while intranasal oxytocin did not show improvement in these areas. Further research is needed to understand the implications and mechanisms of these findings.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Article Neurosciences

An amygdala-to-hypothalamus circuit for social reward

Rongfeng K. Hu et al.

Summary: The study demonstrates that adult mice of both sexes exhibit robust reinforcement of social interaction. Through targeted manipulations, GABAergic neurons in the medial amygdala are found to play a crucial role in promoting the positive reinforcement of social interaction. Additionally, these neurons mediate social reinforcement behavior by projecting to the medial preoptic area and enhancing dopamine release in the nucleus accumbens.

NATURE NEUROSCIENCE (2021)

Article Endocrinology & Metabolism

Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case-Control Study

Selveta S. van Santen et al.

Summary: The study showed that obese patients with craniopharyngioma achieved a substantial mean weight loss of 22% at a 5-year follow-up after bariatric surgery, regardless of the type of surgery performed. The weight loss was lower compared to obese controls after Roux-en-Y gastric bypass, but there were no major changes in hormonal replacement therapy post-surgery.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Review Endocrinology & Metabolism

Childhood-onset Craniopharyngioma

Anna Otte et al.

Summary: Craniopharyngiomas are rare embryonic malformational tumors of low-grade malignancy, often presenting in children with symptoms such as hypothalamic and visual disturbances. Treatment approaches vary based on tumor location, typically involving surgical resection and radiation therapy.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Review Clinical Neurology

Behavioral features in Prader-Willi syndrome (PWS): consensus paper from the International PWS Clinical Trial Consortium

Lauren Schwartz et al.

Summary: Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder characterized by severe hyperphagia and other behavioral challenges, impacting daily functioning and quality of life for individuals with PWS and their families. Effective therapies for these behaviors are still elusive, with a lack of consensus on how to define and measure the complex behavioral features of PWS being a limiting factor for treatment studies.

JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2021)

Review Medicine, General & Internal

Thyroid Function in Adults with Prader-Willi Syndrome; a Cohort Study and Literature Review

Karlijn Pellikaan et al.

Summary: Prader-Willi syndrome (PWS) is a complex genetic syndrome characterized by hypotonia, hyperphagia, and pituitary hormone deficiencies, which can lead to obesity and cardiovascular disease. Exercise is important for reducing high mortality in PWS, and early detection and treatment of hypothyroidism is crucial. Screening for thyroid hormone levels is recommended to avoid negative impacts on metabolic rate, body mass index, and cardiovascular risk.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Oncology

Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007

Svenja Boekhoff et al.

Summary: Cerebral infarction occurs in 11% of surgically-treated craniopharyngioma cases, with risk factors including increased intracranial pressure and extent of surgical resection. CI affects patients' quality of life and function.

FRONTIERS IN ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis

Jose Mario Gonzalez-Meljem et al.

Summary: Cellular senescence can prevent tumour development autonomously but also promote tumour growth non-autonomously by creating a permissive tumour microenvironment. In a specific pituitary tumour ACP, senescent cell clusters with SASP play a critical role in tumour initiation. Evidence suggests that paracrine signalling from senescent cells may underlie tumourigenesis in various tumour and cancer models.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Medicine, General & Internal

ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome-What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review

Cecilia Lazea et al.

Summary: ROHHAD syndrome is a rare disease characterized by rapid-onset obesity, hypoventilation, autonomic dysfunction, and possible neuroendocrine tumors. It has a severe outcome with high morbidity and mortality rates. The etiology of the syndrome remains unknown and debated.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

Review Clinical Neurology

Craniopharyngioma adherence: a reappraisal of the evidence

Ruth Prieto et al.

NEUROSURGICAL REVIEW (2020)

Review Endocrinology & Metabolism

The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis

Elizabeth A. Lawson et al.

JOURNAL OF NEUROENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

The Diagnosis and Treatment of Craniopharyngioma

Hermann L. Mueller

NEUROENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Metabolic Effects of Oxytocin

Shana E. McCormack et al.

ENDOCRINE REVIEWS (2020)

Article Clinical Neurology

Craniopharyngioma in children: trends from a third consecutive single-center cohort study

Hani J. Marcus et al.

JOURNAL OF NEUROSURGERY-PEDIATRICS (2020)

Review Endocrinology & Metabolism

ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis

Julie Harvengt et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Oncology

Predictors of narcolepsy and hypersomnia due to medical disorder in pediatric craniopharyngioma

Belinda N. Mandrell et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

Article Endocrinology & Metabolism

Oxytocin release deficit and social cognition in craniopharyngioma patients

Marie-Luise Brandi et al.

JOURNAL OF NEUROENDOCRINOLOGY (2020)

Review Pediatrics

Chromosome 15 Imprinting Disorders: Genetic Laboratory Methodology and Approaches

Merlin G. Butler et al.

FRONTIERS IN PEDIATRICS (2020)

Article Oncology

Social Cognition in Patients With Hypothalamic-Pituitary Tumors

Jale Oezyurt et al.

FRONTIERS IN ONCOLOGY (2020)

Article Endocrinology & Metabolism

Diagnosis, Background, and Treatment of Hypothalamic Damage in Craniopharyngioma

Eva-Marie Erfurth

NEUROENDOCRINOLOGY (2020)

Article Oncology

The annual incidence of Langerhans cell histiocytosis among adults living in Greece

Polyzois Makras et al.

PEDIATRIC BLOOD & CANCER (2020)

Article Endocrinology & Metabolism

The importance of specialized sleep investigations in children with a suprasellar tumor

J. van Schaik et al.

PITUITARY (2020)

Review Endocrinology & Metabolism

Management of Hypothalamic Obesity

Hermann L. Mueller

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2020)

Review Endocrinology & Metabolism

Update on the Genetics of Pituitary Tumors

Sayka Barry et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2020)

Article Multidisciplinary Sciences

A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region

Clemens Neudorfer et al.

SCIENTIFIC DATA (2020)

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Francesca Petralia et al.

Review Otorhinolaryngology

Gross Total Versus Subtotal Surgical Resection in the Management of Craniopharyngiomas

Maeher R. Grewal et al.

ALLERGY & RHINOLOGY (2020)

Article Pediatrics

Growth hormone treatment in Prader-Willi syndrome patients: systematic review and meta-analysis

Caroline de Gouveia Buff Passone et al.

BMJ PAEDIATRICS OPEN (2020)

Article Endocrinology & Metabolism

Detailed assessment of hypothalamic damage in craniopharyngioma patients with obesity

S. Fjalldal et al.

INTERNATIONAL JOURNAL OF OBESITY (2019)

Article Endocrinology & Metabolism

Low Plasma Oxytocin Levels and Increased Psychopathology in Hypopituitary Men With Diabetes Insipidus

Anna Aulinas et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Endocrinology & Metabolism

Posterior hypothalamus-sparing surgery improves outcome after childhood craniopharyngioma

Agnieszka Bogusz et al.

ENDOCRINE CONNECTIONS (2019)

Review Endocrinology & Metabolism

Childhood-onset craniopharyngioma: state of the art of care in 2018

Hermann L. Mueller

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Endocrinology & Metabolism

Prader-Willi syndrome: A model for understanding the ghrelin system

Maithe Tauber et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

Article Endocrinology & Metabolism

Diagnosing metabolic syndrome in craniopharyngioma patients: body composition versus BMI

Selvetta S. van Santen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Oncology

Targeting IL-6 Is a Potential Treatment for Primary Cystic Craniopharyngioma

Sydney Grob et al.

FRONTIERS IN ONCOLOGY (2019)

Article Medicine, General & Internal

Craniopharyngioma

Hermann L. Mueller et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Article Anatomy & Morphology

Neural networks of aggression: ALE meta-analyses on trait and elicited aggression

Ting Yat Wong et al.

BRAIN STRUCTURE & FUNCTION (2019)

Article Endocrinology & Metabolism

Treatment of Hypothalamic Obesity with Dextroamphetamine: A Case Series

Christian Denzer et al.

OBESITY FACTS (2019)

Article Endocrinology & Metabolism

Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study

Mark Wijnen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

Article Pediatrics

Pediatric prolactinoma: initial presentation, treatment, and long-term prognosis

Anika Hoffmann et al.

EUROPEAN JOURNAL OF PEDIATRICS (2018)

Article Endocrinology & Metabolism

Oxytocin and Naltrexone Successfully Treat Hypothalamic Obesity in a Boy Post-Craniopharyngioma Resection

Eugenie A. Hsu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Behavioral Sciences

The anatomy of apathy: A neurocognitive framework for amotivated behaviour

C. Le Heron et al.

NEUROPSYCHOLOGIA (2018)

Article Medicine, Research & Experimental

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome

Joseph Polex-Wolf et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Oncology

Self- and informant-rated apathy in patients with childhood-onset craniopharyngioma

Aylin Mehren et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

Article Multidisciplinary Sciences

High levels of caregiver burden in Prader-Willi syndrome

Nathalie Kayadjanian et al.

PLOS ONE (2018)

Article Endocrinology & Metabolism

De-masking oxytocin-deficiency in craniopharyngioma and assessing its link with affective function

Dorothea Gebert et al.

PSYCHONEUROENDOCRINOLOGY (2018)

Article Oncology

An Update From the Pediatric Proton Consortium Registry

Clayton B. Hess et al.

FRONTIERS IN ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Effects of craniopharyngioma cyst fluid on neurons and glial cells cultured from rat brain hypothalamus

Mausam Ghosh et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2018)

Article Medicine, Research & Experimental

Intranasal carbetocin reduces hyperphagia in individuals with Prader-Willi syndrome

Elisabeth M. Dykens et al.

JCI INSIGHT (2018)

Article Oncology

Neurocognitive functioning in pediatric craniopharyngioma: performance before treatment with proton therapy

Ashley S. Fournier-Goodnight et al.

JOURNAL OF NEURO-ONCOLOGY (2017)

Article Clinical Neurology

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma

Andrew M. Donson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2017)

Review Endocrinology & Metabolism

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma

Hermann L. Mueller et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Neurosciences

Social Control of Hypothalamus-Mediated Male Aggression

Taehong Yang et al.

NEURON (2017)

Review Behavioral Sciences

Cognition in people with Prader-Willi syndrome: Insights into genetic influences on cognitive and social development

Joyce Whittington et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Genetics & Heredity

Early diagnosis and care is achieved but should be improved in infants with Prader-Willi syndrome

Celine Bar et al.

ORPHANET JOURNAL OF RARE DISEASES (2017)

Review Behavioral Sciences

Pediatric Irritability: A Systems Neuroscience Approach

Ellen Leibenluft

TRENDS IN COGNITIVE SCIENCES (2017)

Article Multidisciplinary Sciences

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Jose Mario Gonzalez-Meljem et al.

NATURE COMMUNICATIONS (2017)

Article Clinical Neurology

Lateral hypothalamic activity indicates hunger and satiety states in humans

Omid Talakoub et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Letter Endocrinology & Metabolism

Hypothalamic obesity after craniopharyngioma surgery: Treatment with a long acting glucagon like peptide 1 derivated

Ines Castro-Dufourny et al.

ENDOCRINOLOGIA DIABETES Y NUTRICION (2017)

Article Endocrinology & Metabolism

Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability

Katie Daughters et al.

ENDOCRINE (2017)

Article Genetics & Heredity

Oxytocin treatment in children with Prader-Willi syndrome: A double-blind, placebo-controlled, crossover study

Jennifer L. Miller et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2017)

Review Pediatrics

The dilemma of diagnostic testing for Prader-Willi syndrome

Arabella Smith et al.

TRANSLATIONAL PEDIATRICS (2017)

Article Endocrinology & Metabolism

Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor

Simon J. B. Aylwin et al.

PITUITARY (2016)

Article Pediatrics

ROHHAD Syndrome: The Girl who Forgets to Breathe

Mukesh Sanklecha et al.

INDIAN PEDIATRICS (2016)

Article Endocrinology & Metabolism

Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial

Raja Brauner et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Endocrinology & Metabolism

Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline

Maria Fleseriu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Clinical Neurology

Spontaneous pituitary adenoma occurring after resection of a Rathke's cleft cyst

Nauman S. Chaudhry et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2016)

Letter Oncology

First report on spinal metastasis in childhood-onset craniopharyngioma

Anika Hoffmann et al.

JOURNAL OF NEURO-ONCOLOGY (2016)

Review Endocrinology & Metabolism

The chronic syndromes after previous treatment of pituitary tumours

Johannes A. Romijn

NATURE REVIEWS ENDOCRINOLOGY (2016)

Article Clinical Neurology

Nucleus accumbens stimulation in pathological obesity

Marek Harat et al.

NEUROLOGIA I NEUROCHIRURGIA POLSKA (2016)

Article Clinical Neurology

Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1

Robert A. Avery et al.

NEUROLOGY (2016)

Article Surgery

Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study

Aayed R. Alqahtani et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2016)

Review Endocrinology & Metabolism

Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity

Hermann L. Mueller

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2016)

Review Health Care Sciences & Services

Growth hormone therapy for Prader-Willi syndrome: challenges and solutions

Graziano Grugni et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2016)

Article Endocrinology & Metabolism

Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas

Pietro Mortini et al.

ENDOCRINE (2016)

Article Endocrinology & Metabolism

Oxytocin in survivors of childhood-onset craniopharyngioma

Anna M. M. Daubenbuechel et al.

ENDOCRINE (2016)

Article Education, Special

Quality of life in children with Prader Willi Syndrome: Parent and child reports

Kathleen S. Wilson et al.

RESEARCH IN DEVELOPMENTAL DISABILITIES (2016)

Article Endocrinology & Metabolism

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

Xiaomeng Liu et al.

ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma

Anika Hoffmann et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Excess Mortality and Morbidity in Patients with Craniopharyngioma, Especially in Patients with Childhood Onset: A Population-Based Study in Sweden

Daniel S. Olsson et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Endocrinology & Metabolism

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models

Juan Pedro Martinez-Barbera et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2015)

Article Endocrinology & Metabolism

Spectrum of clinical presentations and endocrinological findings of patients with septo-optic dysplasia: a retrospective study

Ayse Pinar Cemeroglu et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2015)

Review Clinical Neurology

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma

J. P. Martinez-Barbera

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2015)

Article Endocrinology & Metabolism

Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity

Christian L. Roth et al.

OBESITY (2015)

Review Developmental Biology

Patterning, specification, and differentiation in the developing hypothalamus

Joseph L. Bedont et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Highly restricted deletion of the SNORD116 region is implicated in Prader-Willi Syndrome

Eric Bieth et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2015)

Article Genetics & Heredity

A Double-Blind Randomized Controlled Trial of Oxytocin Nasal Spray in Prader Willi Syndrome

Stewart L. Einfeld et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2014)

Article Oncology

Long-Term Outcomes and Complications in Patients With Craniopharyngioma: The British Columbia Cancer Agency Experience

Andrea C. Lo et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2014)

Article Endocrinology & Metabolism

Diencephalic Syndrome in Childhood Craniopharyngioma-Results of German Multicenter Studies on 485 Long-term Survivors of Childhood Craniopharyngioma

Anika Hoffmann et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Endocrinology & Metabolism

Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study

Jennifer L. Miller et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2014)

Article Endocrinology & Metabolism

Treatment of Hypothalamic Obesity with Caffeine and Ephedrine

Frank Greenway et al.

Endocrine Practice (2013)

Article Endocrinology & Metabolism

GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: report of nine cases

Flavius Zoicas et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)

Article Oncology

Disease Control After Reduced Volume Conformal and Intensity Modulated Radiation Therapy for Childhood Craniopharyngioma

Thomas E. Merchant et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)

Review Endocrinology & Metabolism

Bariatric Surgery Following Treatment for Craniopharyngioma: A Systematic Review and Individual-Level Data Meta-Analysis

Marion Bretault et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Endocrinology & Metabolism

Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome

Cheri L. Deal et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Endocrinology & Metabolism

Childhood Craniopharyngioma: Hypothalamus-Sparing Surgery Decreases the Risk of Obesity

E. Elowe-Gruau et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Editorial Material Endocrinology & Metabolism

Surgical strategy and quality of life in craniopharyngioma

Hermann L. Mueller

NATURE REVIEWS ENDOCRINOLOGY (2013)

Article Multidisciplinary Sciences

The impact of sleep deprivation on food desire in the human brain

Stephanie M. Greer et al.

NATURE COMMUNICATIONS (2013)

Article Clinical Neurology

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

Cynthia L. Andoniadou et al.

ACTA NEUROPATHOLOGICA (2012)

Article Endocrinology & Metabolism

Effects of recombinant human growth hormone therapy in adults with Prader-Willi syndrome: a meta-analysis

Ruth Sanchez-Ortiga et al.

CLINICAL ENDOCRINOLOGY (2012)

Review Genetics & Heredity

Prader-Willi syndrome

Suzanne B. Cassidy et al.

GENETICS IN MEDICINE (2012)

Article Endocrinology & Metabolism

Treatment with Glucagon-Like Peptide-1 Agonist Exendin-4 in a Patient with Hypothalamic Obesity Secondary to Intracranial Tumor

Jill H. Simmons et al.

HORMONE RESEARCH IN PAEDIATRICS (2012)

Article Medicine, Research & Experimental

SOX2 regulates the hypothalamic-pituitary axis at multiple levels

Sujatha A. Jayakody et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Endocrinology & Metabolism

Hypothalamic obesity in children

A. Bereket et al.

OBESITY REVIEWS (2012)

Article Endocrinology & Metabolism

Septo-optic dysplasia and other midline defects: The role of transcription factors: HESX1 and beyond

Mark James McCabe et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Oncology

On the Benefits and Risks of Proton Therapy in Pediatric Craniopharyngioma

Chris Beltran et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)

Article Endocrinology & Metabolism

Consequences of Craniopharyngioma Surgery in Children

Hermann L. Mueller

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Endocrinology & Metabolism

Appetite-Regulating Hormone Changes in Patients With Craniopharyngioma

Christian L. Roth et al.

OBESITY (2011)

Article Multidisciplinary Sciences

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Carles Gaston-Massuet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Endocrinology & Metabolism

Effects of Methylphenidate on Weight Gain and Food Intake in Hypothalamic Obesity

Clinton Thomas Elfers et al.

Frontiers in Endocrinology (2011)

Article Endocrinology & Metabolism

Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy

Jill K. Hamilton et al.

INTERNATIONAL JOURNAL OF PEDIATRIC ENDOCRINOLOGY (2011)

Review Endocrinology & Metabolism

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Joshua P. Thaler et al.

ENDOCRINOLOGY (2010)

Article Biochemistry & Molecular Biology

Septo-optic dysplasia

Emma A. Webb et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2010)

Article Biochemistry & Molecular Biology

Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi syndrome

Angela L. Duker et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2010)

Article Behavioral Sciences

Re-evaluating the role of the mammillary bodies in memory

Seralynne D. Vann

NEUROPSYCHOLOGIA (2010)

Article Clinical Neurology

Radiation therapy for pediatric craniopharyngioma

Erin N. Kiehna et al.

NEUROSURGICAL FOCUS (2010)

Article Pediatrics

Incidence and clinical features of Langerhans cell histiocytosis in the UK and Ireland

J. A. Salotti et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2009)

Article Biochemistry & Molecular Biology

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

Adam J. de Smith et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity

Xiaoqing Zhang et al.

Review Pharmacology & Pharmacy

The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction

Alastair V. Ferguson et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2008)

Article Endocrinology & Metabolism

SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development

Daniel Kelberman et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Endocrinology & Metabolism

Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome in childhood

Pierre Bougneres et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Gastroenterology & Hepatology

Critical analysis of bariatric procedures in Prader-Willi syndrome

A. O. Scheimann et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2008)

Article Oncology

Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000-2004

Aurelie Guyot-Goubin et al.

PEDIATRIC BLOOD & CANCER (2008)

Article Oncology

Incidence of Langerhans cell histiocytosis in children:: A population-based study

Helen Stalemark et al.

PEDIATRIC BLOOD & CANCER (2008)

Article Biochemistry & Molecular Biology

Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

Jocelyn M. Bischof et al.

HUMAN MOLECULAR GENETICS (2007)

Article Endocrinology & Metabolism

Assessment of hyperphagia in Prader-Willi syndrome

Elisabeth M. Dykens et al.

OBESITY (2007)

Article Pediatrics

Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma

Christian L. Roth et al.

PEDIATRIC RESEARCH (2007)

Article Biochemistry & Molecular Biology

Changing rates of genetic subtypes of Prader-Willi syndrome in the UK

Joyce E. Whittington et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2007)

Article Endocrinology & Metabolism

Neural mechanisms underlying hyperphagia in Prader-Willi syndrome

Laura M. Holsen et al.

OBESITY (2006)

Article Endocrinology & Metabolism

Quality of life in treated adult craniopharyngioma patients

OM Dekkers et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2006)

Article Clinical Neurology

Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma

HL Müller et al.

CHILDS NERVOUS SYSTEM (2005)

Article Clinical Neurology

Craniopharyngiomas in children:: Turkey experience

Y Ersahin et al.

CHILDS NERVOUS SYSTEM (2005)

Article Gastroenterology & Hepatology

Neuroendocrine control of food intake

AJ Park et al.

CURRENT OPINION IN GASTROENTEROLOGY (2005)

Article Biochemistry & Molecular Biology

Minimum prevalence, birth incidence and cause of death for Prader-Willi syndrome in Flanders

A Vogels et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2004)

Article Endocrinology & Metabolism

Octreotide therapy of pediatric hypothalamic obesity: A double-blind, placebo-controlled trial

RH Lustig et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Endocrinology & Metabolism

Role of melatonin in the regulation of human circadian rhythms and sleep

C Cajochen et al.

JOURNAL OF NEUROENDOCRINOLOGY (2003)

Article Pediatrics

Birth prevalence of Prader-Willi syndrome in Australia

A Smith et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2003)

Article Endocrinology & Metabolism

11 beta-hydroxysteroid dehydrogenase activity in hypothalamic obesity

D Tiosano et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Endocrinology & Metabolism

Obesity in patients with craniopharyngioma: Assessment of food intake and movement counts indicating physical activity

KJ Harz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Pediatrics

The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma

PW Mason et al.

ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE (2002)

Article Multidisciplinary Sciences

Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure

SC Ahlgren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Clinical Neurology

Pediatric craniopharyngiomas: Clinicomorphological study of 189 cases

YQ Zhang et al.

PEDIATRIC NEUROSURGERY (2002)

Article Clinical Neurology

Mazindol administration improved hyperphagia after surgery for craniopharyngiomo - Case report

T Sadatomo et al.

NEUROLOGIA MEDICO-CHIRURGICA (2001)

Article Clinical Neurology

Applied behavior management and acquired brain injury: Approaches and assessment

BB Yody et al.

JOURNAL OF HEAD TRAUMA REHABILITATION (2000)

Article Developmental Biology

Fate mapping of the mouse prosencephalic neural plate

T Inoue et al.

DEVELOPMENTAL BIOLOGY (2000)