Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes

Chitosan films are increasingly being applied in the biomedical field owing to their biocompatibility, biodegradability, non-toxicity, mucoadhesive nature, hemostatic properties, antibacterial and biological activities. This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations (100-300 mu g). The NS-SagNPs were prepared by a thin-film hydration process with an average particle size of 21.5 nm. The doped chitosan films were fabricated through a simple casting method. FTIR and DSC measurements confirmed the successful incorporation of NS-SagNPs in the chitosan films. The mechanical properties of the doped films were improved and the most significant improvement was found in tensile strength and elasticity when the NS-SagNPs loading was increased to 300 mu g. Based on these results, chitosan films doped with NS-SagNPs have the advantageous feature of sage and show enhanced mechanical properties compared with pure chitosan, rendering them more suitable for biomedical applications.

Automated summary

This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations. The doped films showed improved mechanical properties, particularly in tensile strength and elasticity, when the NS-SagNPs loading was increased to 300 μg.