Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 16, Issue 4, Pages 515-530Publisher
SPRINGER
DOI: 10.1007/s12079-022-00674-2
Keywords
Periostin; Extracellular matrix; Integrins; Signaling pathways; Crosstalk
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Funding
- Special fund project for doctoral training program of Lanzhou University Second Hospital [YJS-BD-09]
- Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital [CY2021-QN-A19, CY2020-MS20]
- Gansu Natural Science Foundation [20JR10RA717]
- Lanzhou Science and Technology Development Guiding Project [2020-ZD-95]
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This article explores the interactions between POSTN and different signaling pathways in various diseases, providing insights into the mechanisms of disease occurrence and development. It also offers novel guidelines for the development of targeted therapies.
Matricellular proteins are responsible for regulating the microenvironment, the behaviors of surrounding cells, and the homeostasis of tissues. Periostin (POSTN), a non-structural matricellular protein, can bind to many extracellular matrix proteins through its different domains. POSTN usually presents at low levels in most adult tissues but is highly expressed in pathological sites such as in tumors and inflamed organs. POSTN can bind to diverse integrins to interact with multiple signaling pathways within cells, which is one of its core biological functions. Increasing evidence shows that POSTN can activate the TGF-beta, the PI3K/Akt, the Wnt, the RhoA/ROCK, the NF-kappa B, the MAPK and the JAK pathways to promote the occurrence and development of many diseases, especially cancer and inflammatory diseases. Furthermore, POSTN can interact with some pathways in an upstream and downstream relationship, forming complicated crosstalk. This article focuses on the interactions between POSTN and different signaling pathways in diverse diseases, attempting to explain the mechanisms of interaction and provide novel guidelines for the development of targeted therapies.
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