4.8 Article

Extracellular Traps Increase Burden of Bleeding by Damaging Endothelial Cell in Acute Promyelocytic Leukaemia

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Neutrophils, Cancer and Thrombosis: The New Bermuda Triangle in Cancer Research

Melanie Langiu et al.

Summary: Neutrophils play a crucial role in both cancer-associated thrombosis (CAT) and cancer progression, impacting thrombus formation through the release of cytokines and expression of molecules, and promoting metastasis and immune suppression by attracting neutrophils to the tumor site.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

Neutrophil Extracellular Traps Are Increased in Chronic Myeloid Leukemia and Are Differentially Affected by Tyrosine Kinase Inhibitors

Alona Telerman et al.

Summary: Neutrophil extracellular traps (NETs) are increased in chronic myeloid leukemia (CML) and certain drugs used to treat CML (tyrosine kinase inhibitors-TKIs) further increase NET formation, suggesting a possible link between CML, TKIs, and vascular toxicity.

CANCERS (2022)

Review Allergy

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

Victoria Mutua et al.

Summary: Activated neutrophils release NETs to capture and destroy microbes, but they also cause inflammation and tissue damage. The role of NETs in autoimmune and autoinflammatory diseases is being studied, and inhibition of NETosis may reduce disease severity.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Dynamic Changes in the Ability to Release Neutrophil ExtraCellular Traps in the Course of Childhood Acute Leukemias

Magdalena Ostafin et al.

Summary: Patients with acute leukemia exhibit significantly impaired release of NETs by neutrophils during both the course of the disease and treatment, with full restoration of neutrophil function achieved only after successful completion of treatment. This impairment may be attributed to disease- and treatment-related factors, contributing to the deficient innate immune response and secondary immunodeficiency observed in this population.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke

Shuoqi Zhang et al.

Summary: This study explored the role of circulating neutrophil extracellular traps (NETs) in tissue plasminogen activator (t-PA) resistance in acute ischemic stroke patients. The NETs were found to activate platelets and endothelial cells, affecting the coagulation and fibrinolysis process. Targeting NETs may be a promising therapeutic approach to enhance the efficacy of t-PA thrombolysis in AIS patients.

FASEB JOURNAL (2021)

Article Oncology

Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL-8

Carlos E. de Andrea et al.

Summary: NETs are present in various human solid tumors and are associated with IL-8 protein expression and CD8(+) T-cell density in the tumor microenvironment. There is individual variation in NET density across different cancer types, with a positive correlation with IL-8 and a trend towards a negative association with CD8(+) TILs.

JOURNAL OF PATHOLOGY (2021)

Review Oncology

Neutrophil Extracellular Traps (NETs) in Cancer Invasion, Evasion and Metastasis

Urszula Demkow

Summary: This review focuses on the pro-tumorigenic action of neutrophil extracellular traps (NETs), which are found in various human and animal tumors. NETs play a crucial role in tumor development by awakening dormant cancer cells, regulating the tumor microenvironment, and enhancing tumor aggressiveness. Understanding the crosstalk between cancer and NETs can lead to novel therapeutic interventions to block cancer evasion mechanisms and prevent metastatic spread.

CANCERS (2021)

Review Oncology

The Role of Neutrophil Extracellular Traps in Cancer

Bo-Zong Shao et al.

Summary: Neutrophil extracellular traps (NETs) play a vital role in the immune response, combating microbial infections and influencing the pathogenesis of various diseases. This review highlights the biological characteristics of NETs and their mechanisms in cancer, providing insights into potential therapeutic targets.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Predictors of early hemorrhage in acute promyelocytic leukemia

Leonard Naymagon et al.

LEUKEMIA & LYMPHOMA (2019)

Article Multidisciplinary Sciences

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Jose Perdomo et al.

NATURE COMMUNICATIONS (2019)

Article Clinical Neurology

Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury

Jyoti Gautam et al.

TRANSLATIONAL STROKE RESEARCH (2019)

Article Biochemistry & Molecular Biology

Citrullinated histone 3 causes endothelial barrier dysfunction

Jamie E. Meegan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Host DNases prevent vascular occlusion by neutrophil extracellular traps

Miguel Jimenez-Alcazar et al.

SCIENCE (2017)

Article Hematology

Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition

Elmar Pieterse et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Article Cell Biology

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

Juwon Park et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Immunology

Neutrophil Extracellular Traps in ANCA-Associated Vasculitis

Daniel Soderberg et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

Elzbieta Kolaczkowska et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes

Emilie Lukasova et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Medicine, Research & Experimental

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

Axelle Caudrillier et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Multidisciplinary Sciences

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

Melanie Demers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell Biology

Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1

Ronen Sumagin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Article Cell Biology

Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity

Jamie R. Privratsky et al.

JOURNAL OF CELL SCIENCE (2011)

Article Hematology

Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia

J. Zhou et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

Review Genetics & Heredity

Regulation of vascular integrity

Masahiro Murakami et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2009)

Article Medicine, General & Internal

The immunodeficiency of chronic lymphocytic leukaemia

A. D. Hamblin et al.

BRITISH MEDICAL BULLETIN (2008)

Article Biochemistry & Molecular Biology

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Stephen R. Clark et al.

NATURE MEDICINE (2007)

Article Multidisciplinary Sciences

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

J Kisucka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cardiac & Cardiovascular Systems

Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability

JW Breslin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Article Cell Biology

Src-dependent, neutrophil-mediated vascular hyperpermeability and β-catenin modification

JH Tinsley et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

Article Medicine, General & Internal

Efficacy and safety of recombinant human activated protein C for severe sepsis.

GR Bernard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)