Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.859414
Keywords
imaging mass cytometry; hyperion; cancer research; biomarker; tumoral microenvironment
Categories
Funding
- Agence Nationale de la Recherche under the Investissementd'Avenir program [ANR-11-LABX-0016-001]
- European FEDER [RU 000950]
- La Ligue contre le cancer
Ask authors/readers for more resources
Imaging mass cytometry (IMC) allows for the analysis of in-depth-phenotyped cells in their native microenvironment within tissue sections, aiding in the identification of biomarkers for cancer treatment and improving understanding of cancer progression and immune system resistance mechanisms.
Imaging mass cytometry (IMC) enables the in situ analysis of in-depth-phenotyped cells in their native microenvironment within the preserved architecture of a single tissue section. To date, it permits the simultaneous analysis of up to 50 different protein- markers targeted by metal-conjugated antibodies. The application of IMC in the field of cancer research may notably help 1) to define biomarkers of prognostic and theragnostic significance for current and future treatments against well-established and novel therapeutic targets and 2) to improve our understanding of cancer progression and its resistance mechanisms to immune system and how to overcome them. In the present article, we not only provide a literature review on the use of the IMC in cancer-dedicated studies but we also present the IMC method and discuss its advantages and limitations among methods dedicated to deciphering the complexity of cancer tissue.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available