4.8 Article

Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

Maria N. Navarro et al.

Summary: Immune metabolism is closely related to cellular functions such as energy metabolism and inflammation. The manipulation of NAD(+) availability through pharmacological compounds can have immune-modulatory properties in inflammation, offering opportunities for therapeutic intervention in inflammatory disorders.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

A Method to Monitor the NAD+ Metabolome-From Mechanistic to Clinical Applications

Maria Pilar Giner et al.

Summary: NAD(+) and its reduced form NADH are essential coenzymes in hundreds of metabolic reactions, serving as substrates for key enzymes. Analyzing the NAD(+) metabolome using liquid chromatography-tandem mass spectrometry can provide insights into NAD(+) biology and its implications for health and disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Preclinical and clinical evidence of NAD plus precursors in health, disease, and ageing

Ole Kristian Reiten et al.

Summary: NAD+ is a crucial molecule in human life and health, with age-related decline in cellular NAD+ levels. However, NAD+ precursor supplementation can potentially extend lifespan, mitigate diseases, and have therapeutic potential for aging-related conditions.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Biochemistry & Molecular Biology

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

Andrey Kropotov et al.

Summary: Nicotinamide riboside can be imported into cells by equilibrative nucleoside transporters, while nicotinic acid riboside requires active utilization in the cytosol before being taken up by HEK293 cells. Concentrative nucleoside transporters do not mediate the uptake of nicotinamide riboside.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Keisuke Yaku et al.

Summary: Nicotinamide riboside increases NAD(+) levels through two pathways, directly generating NAD(+) via the NR salvage pathway and contributing to NAD(+) production through the Preiss-Handler pathway after being hydrolyzed by BST1.

NATURE COMMUNICATIONS (2021)

Review Nutrition & Dietetics

Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects

Ekaterina Podyacheva et al.

Summary: Despite the progress in developing new anticancer strategies, the issue of doxorubicin cardiotoxicity remains unresolved. Nicotinamide riboside, a precursor to NAD(+), shows potential in addressing this problem, although there is limited research on its effects on cardiomyopathy.

NUTRIENTS (2021)

Article Multidisciplinary Sciences

CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1

Yuliya Yakymiv et al.

Summary: CD157, a member of the ADP-ribosyl cyclase family, is expressed at variable levels in 97% of patients with acute myeloid leukemia (AML). Antibodies targeting CD157 enhance AML cell survival, decrease apoptosis, and reduce the toxicity of the chemotherapy drug AraC. This study suggests a potential role for CD157 as a predictive marker of response to therapies exploiting Mcl-1 pharmacological inhibition.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Enzymology of extracellular NAD metabolism

Massimiliano Gasparrini et al.

Summary: Extracellular NAD serves as a key signaling molecule in different physiological and pathological conditions, regulated by a variety of enzymes. The enzymatic activities involved in extracellular NAD metabolism play important roles in controlling immune responses, inflammatory processes, tumorigenesis, and other diseases. Further research is needed to explore the therapeutic potential of these enzymes as targets for various human diseases.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice

Ruben Zapata-Perez et al.

Summary: NMNH, as a new NAD(+) precursor, significantly increases NAD(+) levels and reduces damage through a unique metabolic pathway. Administration of NMNH in mice leads to a rapid surge in NAD(+) levels, demonstrating its potential for treating acute kidney injury.

FASEB JOURNAL (2021)

Article Biochemical Research Methods

Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth

Yan Liu et al.

Summary: The study demonstrates that NMNH is a potent enhancer of NAD(+) and suppresses glycolysis, the TCA cycle, and cell growth. NMNH, produced through a chemical method, is more effective than NMN in increasing NAD(+) levels in vivo and in vitro, mediated by NMNAT.

JOURNAL OF PROTEOME RESEARCH (2021)

Article Medicine, Research & Experimental

Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages

Hyunju Kang et al.

Summary: Nicotinamide riboside (NR), a natural nicotinamide adenine dinucleotide (NAD(+)) precursor, exerts anti-inflammatory and antioxidant properties by activating sirtuin 1 in alcohol-stimulated macrophages. Additionally, NR counteracts hypoxia-induced factor 1 alpha-induced metabolic reprogramming favoring lactate formation. The effects of NR are likely attributable to the replenishment of the cellular NAD(+) pool depleted by metabolizing ethanol.

LABORATORY INVESTIGATION (2021)

Review Immunology

The Key Role of NAD+ in Anti-Tumor Immune Response: An Update

Fabio Morandi et al.

Summary: NAD(+) is a crucial molecule in metabolic processes, with CD38 playing a key role in immunosuppression in various types of tumors.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer

Anita K. Mehta et al.

Summary: Macrophages play a significant role in breast cancer progression, with their infiltration associated with poor prognosis. Tumor-associated macrophages impede productive tumor immunity by limiting antigen presentation and supporting tumor cell survival, angiogenesis, and metastasis, highlighting the urgent need to overcome their immune suppression for durable anti-tumor immunity in breast cancer.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus

Yueqi Qiu et al.

Summary: SLE is a potentially fatal multisystem inflammatory disorder characterized by abnormal immune responses, and SIRT1, as a key regulator in immune cells, may play important roles in the pathogenesis of SLE.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

The Extracellular NADome Modulates Immune Responses

Valentina Audrito et al.

Summary: NADome refers to the complex network of enzymes that regulate the synthesis or degradation of NAD, both intracellularly and extracellularly, as well as the receptors involved. Recent studies have shown that NAD has biological activity outside of cells, potentially linked to immunomodulation and non-enzymatic activities. Extracellular NAD can trigger inflammatory responses, similar to ATP.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages

Jing Liu et al.

Summary: The study identified that a decrease in cellular NAD(+) levels contributes to macrophage activation, while NMN supplementation can restore NAD(+) levels and inhibit macrophage activation. NMN inactivated macrophages via the COX-2-PGE(2) pathway.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Immunology

ACOD1 in immunometabolism and disease

Runliu Wu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Review Immunology

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

Zayda L. Piedra-Quintero et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Endocrinology & Metabolism

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Claudia C. S. Chini et al.

NATURE METABOLISM (2020)

Article Endocrinology & Metabolism

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Anthony J. Covarrubias et al.

NATURE METABOLISM (2020)

Review Biochemistry & Molecular Biology

NAD+metabolism: pathophysiologic mechanisms and therapeutic potential

Na Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Endocrinology & Metabolism

NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase

Yue Yang et al.

NATURE METABOLISM (2020)

Article Cell Biology

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli et al.

NATURE CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Dihydronicotinamide riboside is a potent NAD+ concentration enhancer in vitro and in vivo

Yue Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Immunology

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

Michael G. Dorrington et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cell Biology

Itaconate: an emerging determinant of inflammation in activated macrophages

Xiao-Hua Yu et al.

IMMUNOLOGY AND CELL BIOLOGY (2019)

Review Biochemical Research Methods

Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy

Qin Zeng et al.

CURRENT OPINION IN BIOTECHNOLOGY (2019)

Review Cell Biology

Metabolism as a guiding force for immunity

Jonathan Jung et al.

NATURE CELL BIOLOGY (2019)

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Endocrinology & Metabolism

Slc12a8 is a nicotinamide mononucleotide transporter

Alessia Grozio et al.

NATURE METABOLISM (2019)

Article Cell Biology

CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

Shilpak Chatterjee et al.

CELL METABOLISM (2018)

Review Pharmacology & Pharmacy

NAMPT: A pleiotropic modulator of monocytes and macrophages

Cristina Travelli et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Immunology

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

Stephanie A. Amici et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Urology & Nephrology

Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner

Yi Guan et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Biochemistry & Molecular Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Joe Dan Dunn et al.

REDOX BIOLOGY (2015)

Article Multidisciplinary Sciences

Novel Markers to Delineate Murine M1 and M2 Macrophages

Kyle A. Jablonski et al.

PLOS ONE (2015)

Article Biochemistry & Molecular Biology

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells

Alessia Grozio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)