☆ 4.8 Article

A First for Human Vaccinology: GMP Compliant Radiation Attenuation of Plasmodium falciparum Sporozoites for Production of a Vaccine Against Malaria

FRONTIERS IN IMMUNOLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Infectious Diseases

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial

Mahamadou S. Sissoko et al.

Summary: A clinical trial was conducted in Mali to evaluate the safety, immunogenicity, and protective efficacy of the PfSPZ Vaccine in preventing malaria infection. The study found that the three-dose regimen of the vaccine was safe, well tolerated, and conferred 51% vaccine efficacy against natural P falciparum transmission.

LANCET INFECTIOUS DISEASES (2022)

Add to Collection

Article Immunology

Multidose Priming and Delayed Boosting Improve Plasmodium falciparum Sporozoite Vaccine Efficacy Against Heterologous P. falciparum Controlled Human Malaria Infection

Kirsten E. Lyke et al.

Summary: The study demonstrated that administering four stacked priming injections resulted in 40% vaccine efficacy against heterologous malaria infection, while dose escalation of PfSPZ using single-dose priming was not significantly protective. Boosting unprotected subjects improved effectiveness to 64% at 24 weeks.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults

Said A. Jongo et al.

Summary: In African vaccinees, Plasmodium falciparum sporozoite-CVac recipients demonstrated a higher vaccine efficacy, likely due to later stage parasite maturation leading to induction of cellular immunity against a broader array of antigens.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

Add to Collection

Article Microbiology

PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection

Sean C. Murphy et al.

Summary: The study evaluated different dosing schedules of PfSPZ-CVac vaccine and found that a higher dose given with a shorter interval achieved better vaccine efficacy, while administering the vaccine during blood-stage parasitemia resulted in almost no efficacy. This suggests that blood-stage infections may impair the protective responses to malaria.

PLOS PATHOGENS (2021)

Add to Collection

Article Immunology

Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults

Said A. Jongo et al.

CLINICAL INFECTIOUS DISEASES (2020)

Add to Collection

Article Immunology

Infectious Sporozoites of Plasmodium berghei Effectively Activate Liver CD8α+ Dendritic Cells

Rajesh Parmar et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Benjamin Mordmueller et al.

NATURE (2017)

Add to Collection

Article Medicine, Research & Experimental

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

Judith E. Epstein et al.

JCI INSIGHT (2017)

Add to Collection

Article Infectious Diseases

Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naive volunteers: effect of injection volume and dose on infectivity rates

Gloria P. Gomez-Perez et al.

MALARIA JOURNAL (2015)

Add to Collection

Article Infectious Diseases

Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres

Benjamin Mordmueller et al.

MALARIA JOURNAL (2015)

Add to Collection

Article Immunology

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

Thomas L. Richie et al.

VACCINE (2015)

Add to Collection

Article Multidisciplinary Sciences

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Robert A. Seder et al.

SCIENCE (2013)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Radiochromic film dosimetry: Past, present, and future

Slobodan Devic

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2011)

Add to Collection

Article Multidisciplinary Sciences

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

J. E. Epstein et al.

SCIENCE (2011)

Add to Collection

Article Immunology

The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine

Rana Chattopadhyay et al.

VACCINE (2009)

Add to Collection

Article Parasitology

Plasmodium falciparum:: Effect of radiation on levels of gene transcripts in sporozoites

Benjamin U. Hoffman et al.

EXPERIMENTAL PARASITOLOGY (2008)

Add to Collection

Article Immunology

Protracted protection to Plasmodium berghei malaria is linked to functionally and phenotypically heterogeneous liver memory CD8+ T cells

D Berenzon et al.

JOURNAL OF IMMUNOLOGY (2003)

Add to Collection

Article Immunology

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

SL Hoffman et al.

JOURNAL OF INFECTIOUS DISEASES (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.