Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.864298
Keywords
CD8(+) T cell; SARS-CoV-2; cancer; exhaustion; memory T cell; immune checkpoint inhibitor (ICI); hypoxia; programmed death 1 receptor (PD-1)
Categories
Funding
- Kurdistan University of Medical Sciences [IR.MUK.REC.1400.154]
Ask authors/readers for more resources
Dysregulated immune responses, particularly the dysfunction of CD8(+) T cells, play a significant role in SARS-CoV-2-induced disease and cancer. Overactive CD8(+) T cells in the lung and tumor microenvironment become exhausted and undergo apoptosis, leading to diminished immunity. Therefore, strategies to restore the functionality of CD8(+) T cells are crucial for overcoming these diseases.
Dysregulated innate and adaptive immunity is a sign of SARS-CoV-2-induced disease and cancer. CD8(+) T cells are important cells of the immune system. The cells belong to the adaptive immunity and take a front-line defense against viral infections and cancer. Extreme CD8(+) T-cell activities in the lung of patients with a SARS-CoV-2-induced disease and within the tumor microenvironment (TME) will change their functionality into exhausted state and undergo apoptosis. Such diminished immunity will put cancer cases at a high-risk group for SARS-CoV-2-induced disease, rendering viral sepsis and a more severe condition which will finally cause a higher rate of mortality. Recovering responses from CD8(+) T cells is a purpose of vaccination against SARS-CoV-2. The aim of this review is to discuss the CD8(+) T cellular state in SARS-CoV-2-induced disease and in cancer and to present some strategies for recovering the functionality of these critical cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available