4.8 Article

IL-38 Gene Deletion Worsens Murine Colitis

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

IL-38-mediated NLRP3/caspase-1 inhibition is a disease-modifying treatment for TMJ inflammation

Ping Luo et al.

Summary: The study demonstrates that IL-38 can alleviate inflammatory responses in chondrocytes by inhibiting the expression of inflammatory cytokines and related pathways. IL-38 limits inflammation and delays cartilage degeneration in the TMJ.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2022)

Article Chemistry, Multidisciplinary

IL-36 gamma and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling

Wei Yang et al.

Summary: This study reveals the crucial role of IL-36 gamma and IL-36Ra in gut inflammation and tumorigenesis. IL-36 gamma promotes inflammation and colon cancer development, while IL-36Ra alleviates inflammation and inhibits tumor growth. Targeting the IL-36 gamma/IL-36Ra signal balance may provide a potential therapeutic strategy for inflammatory bowel disease and gastrointestinal cancers.

ADVANCED SCIENCE (2022)

Article Gastroenterology & Hepatology

NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis

Tomofumi Oizumi et al.

Summary: The study demonstrated that OLT1177 effectively prevented the onset of DSS colitis in mice, with administration during the induction phase showing significant reductions in inflammatory markers. However, giving OLT1177 during the recovery phase had minimal impact on the disease progression.

DIGESTIVE DISEASES AND SCIENCES (2022)

Article Allergy

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development

Lingli Zhou et al.

Summary: A rare NLRP3 variant was identified in 3 patients with gastrointestinal symptoms, which increased NLRP3 inflammasome activation and pyroptosis in macrophages. In a dextran sulfate sodium-induced acute colitis model, the variant in hematopoietic cells resulted in more severe colitis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

Dennis M. de Graaf et al.

Summary: IL-38 exhibits significant anti-inflammatory properties in murine models, effectively reducing arthritis and systemic inflammation, showing potential as a cytokine therapy.

CYTOKINE (2021)

Article Immunology

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

Dennis M. de Graaf et al.

Summary: IL-38 (IL1F10) suppresses inflammatory and autoimmune conditions and its plasma concentrations in healthy Europeans correlate positively with circulating memory B cells and plasmablasts. In individuals at high risk for cardiovascular disease, IL-38 levels were significantly lower and correlated inversely with markers of inflammation. This suggests a potential role for IL-38 deficiency in aging-related systemic inflammation and diseases.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats

Sameh Saber et al.

Summary: The study showed that the P2X7R blocker BBG and the selective NLRP3 inhibitor OLT1177, when used individually or in combination, effectively treated ulcerative colitis by reducing inflammation and repairing colonic damage. The combined administration of BBG and OLT1177 exhibited a stronger inhibitory effect on NLRP3 signaling.

LIFE SCIENCES (2021)

Article Oncology

Interleukin-38 in colorectal cancer: a potential role in precision medicine

Feier Chen et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

Article Allergy

The microbiome and inflammatory bowel disease

Kerri L. Glassner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Emerging treatments for inflammatory bowel disease

Karl Hazel et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2020)

Review Biochemistry & Molecular Biology

Focus on the Role of NLRP3 Inflammasome in Diseases

Roberta Fusco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Pharmacology & Pharmacy

CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells

Fang Bian et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Immunology

Innate immunity to intracellular LPS

Vijay A. K. Rathinam et al.

NATURE IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

IL-38: A New Player in Inflammatory Autoimmune Disorders

Lihui Xie et al.

BIOMOLECULES (2019)

Article Public, Environmental & Occupational Health

Mendelian randomization analysis of C-reactive protein on colorectal cancer risk

Xiaoliang Wang et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

Article Multidisciplinary Sciences

Neutralization of IL-1α ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome

Paola Menghini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Gastroenterology & Hepatology

Colorectal Cancer in Inflammatory Bowel Disease

Ryan W. Stidham et al.

CLINICS IN COLON AND RECTAL SURGERY (2018)

Article Biotechnology & Applied Microbiology

Differential Expression of IL-36 Family Members and IL-38 by Immune and Nonimmune Cells in Patients with Active Inflammatory Bowel Disease

Gabriela Fonseca-Camarillo et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Immunology

Inflammatory cell death in intestinal pathologies

Deepika Sharma et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Immunology

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage

Oscar Medina-Contreras et al.

JOURNAL OF IMMUNOLOGY (2016)

Meeting Abstract Gastroenterology & Hepatology

IL-36 Receptor Is Required for Resolution of Intestinal Damage

Akihito Harusato et al.

INFLAMMATORY BOWEL DISEASES (2016)

Article Gastroenterology & Hepatology

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

Marina Bersudsky et al.

Article Multidisciplinary Sciences

Paneth cells as a site of origin for intestinal inflammation

Timon E. Adolph et al.

NATURE (2013)

Article Multidisciplinary Sciences

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

Frank L. van de Veerdonk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Janice J. Kim et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)

Article Genetics & Heredity

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

Alexandra-Chloe Villani et al.

NATURE GENETICS (2009)

Letter Immunology

The NLR gene family: A standard nomenclature

Jenny P. -Y. Ting et al.

IMMUNITY (2008)

Review Immunology

Intracellular NOD-like receptors in host Defense and disease

Thirumala-Devi Kanneganti et al.

IMMUNITY (2007)

Review Medicine, General & Internal

Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine

Philippe Goyette et al.

ANNALS OF MEDICINE (2007)

Review Biochemistry & Molecular Biology

Pathogen recognition and innate immunity

S Akira et al.

Article Gastroenterology & Hepatology

Increased expression of interleukin 17 in inflammatory bowel disease

S Fujino et al.

Review Medicine, General & Internal

Inflammatory bowel disease

DK Podolsky

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Biochemistry & Molecular Biology

Cloning and characterization of IL-1HY2, a novel interleukin-1 family member

HS Lin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)