Journal
CRYSTALS
Volume 12, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/cryst12060779
Keywords
green synthesis; ZnO nanoparticles; antibacterial activity; anticancer activity; fruit peels; water hyacinth
Funding
- Kasetsart University through the Graduate School Fellowship Program - National Research Council of Thailand [Aor-Por-Sor 96/2563]
- Kasetsart University Research and Development Institute (KURDI), Bangkok, Thailand
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This study successfully synthesized ZnO NPs using bioactive compounds derived from waste materials and investigated their antibacterial and anticancer activities. The green-synthesized ZnO NPs showed significant antibacterial effects and demonstrated potential anti-skin cancer activity in vitro.
Green synthesis of zinc oxide nanoparticles (ZnO NPs) has recently gained considerable interest because it is simple, environmentally friendly, and cost-effective. This study therefore aimed to synthesize ZnO NPs by utilizing bioactive compounds derived from waste materials, mangosteen peels, and water hyacinth crude extracts and investigated their antibacterial and anticancer activities. As a result, X-ray diffraction analysis confirmed the presence of ZnO NPs without impurities. An ultraviolet-visible absorption spectrum showed a specific absorbance peak around 365 nm with an average electronic band gap of 2.79 eV and 2.88 eV for ZnO NPs from mangosteen peels and a water hyacinth extract, respectively. An SEM analysis displayed both spherical shapes of ZnO NPs from the mangosteen peel extract (dimension of 154.41 x 172.89 nm) and the water hyacinth extract (dimension of 142.16 x 160.30 nm). Fourier transform infrared spectroscopy further validated the occurrence of bioactive molecules on the produced ZnO NPs. By performing an antibacterial activity assay, these green synthesized ZnO NPs significantly inhibited the growth of Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri, and Ralstonia solanacearum. Moreover, they demonstrated potent anti-skin cancer activity in vitro. Consequently, this study demonstrated the possibility of using green-synthesized ZnO NPs in the development of antibacterial or anticancer agents. Furthermore, this research raised the prospect of increasing the value of agricultural waste.
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