Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)

Article Biotechnology & Applied Microbiology

CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis

Lanfang Fu et al.

Summary: circ_0071269 promotes the development of diabetic cardiomyopathy through the miR-145/GSDMA axis, and may serve as a novel marker for the treatment of DCM.

BIOENGINEERED (2022)

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Article Biotechnology & Applied Microbiology

CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis

Lihuan Zhu et al.

Summary: Circular RNA circMMD_007 was found to be abnormally upregulated in lung adenocarcinoma and could promote the oncogenic effects in the progression of LC through the miR-197-3p/PTPN9 axis.

BIOENGINEERED (2022)

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Review Oncology

Integration of immunotherapy into treatment of cervical cancer: Recent data and ongoing trials

Bradley J. Monk et al.

Summary: Cervical cancer is a major health burden for women worldwide, and immunotherapies have shown potential in treating high-risk cases. However, there are challenges in accessing and affording these treatments, especially in low- and middle-income countries.

CANCER TREATMENT REVIEWS (2022)

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Review Oncology

Treatment Strategies and Prognostic Factors of 2018 FIGO Stage IIIC Cervical Cancer: A Review

Fengying Qin et al.

Summary: This review discusses the treatment options for stage IIIC cervical cancer and the impact of different lymph node status parameters on prognosis. The current FIGO staging system, while considering the anatomical location of metastatic lymph nodes, does not take into account other important LN status parameters, potentially limiting its prognostic significance and necessitating further research and confirmation.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2022)

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Article Oncology

The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex

Mingyi Zhou et al.

Summary: This study identified an upregulated circRNA signature in cervical cancer tissues, with circZFR being significantly overexpressed and promoting cell proliferation, invasion, and tumor growth. Functional experiments revealed circZFR's interaction with SSBP1, leading to the assembly of CDK2/cyclin E1 complexes and activation of cell cycle progression and proliferation. These findings suggest circZFR as a potential biomarker and therapeutic target for cervical cancer patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Cell Biology

Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis

Chunyu Zhang et al.

Summary: The circRNA derived from the TADA2A gene, hsa_circ_0043280, is significantly downregulated in cervical cancer (CCa) and plays a crucial role in inhibiting tumor growth and metastasis by competitively sponging miR-203a-3p. The findings suggest that hsa_circ_0043280 has the potential to serve as a prognostic biomarker and therapeutic target for CCa.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4

Zhaoxin Wang et al.

Aging-US (2021)

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Article Cell Biology

LncRNA lnc-ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR-486-5p/NFAT5

Yu-Rui Duan et al.

Summary: The study showed that lncRNA lnc-ISG20 is up-regulated in the glomerular of patients with diabetic nephropathy (DN). Silencing lnc-ISG20 alleviated fibrosis in kidney cells and delayed renal fibrosis in DN mice. The downstream miRNA of lnc-ISG20, miR-486-5p, was found to inhibit NFAT5 expression by binding to its 3'UTR.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Respiratory System

Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis

Junli Sun et al.

Summary: Long noncoding RNA SNHG16 plays a role in sepsis-induced acute lung injury by regulating the miR-128-3p/HMGB3 pathway. Upregulation of SNHG16 and HMGB3, along with downregulation of miR-128-3p, exacerbates inflammation and apoptosis in sepsis-induced ALI. Inhibiting SNHG16 can alleviate ALI by modulating the miR-128-3p/HMGB3 axis.

BMC PULMONARY MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429

Yute Sun et al.

Summary: The study revealed that circRNA_0082835 impacts melanoma cells and lymphatic metastasis by sponging miR-429, affecting tumor malignancy and metastatic potential.

BIOENGINEERED (2021)

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Article Pharmacology & Pharmacy

MiRNA-873-5p Acts as a Potential Novel Biomarker and Promotes Cervical Cancer Progression by Regulating ZEB1 via Notch Signaling Pathway

Chen-Xia Wen et al.

Summary: Our study demonstrated that low expression of miRNA-873-5p in cervical cancer patients was significantly associated with distant metastasis, FIGO stage, and poor prognosis. Overexpression of miRNA-873-5p suppressed cell proliferation and metastasis, while promoting apoptosis. Bioinformatic analysis suggested that miRNA-873-5p may target ZEB1 and inhibit its translation.

DOSE-RESPONSE (2021)

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Article Biotechnology & Applied Microbiology

Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression

Qiao Gu et al.

Summary: Circ-ZNF609, as an oncogene, promotes the progression of cervical cancer by modulating the miR-197-3p/E2F6 axis. This finding provides a unique insight into the molecular mechanisms of cervical cancer and suggests a potential therapeutic target.

BIOENGINEERED (2021)

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Article Cell & Tissue Engineering

Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer

Xia Zhang et al.

Summary: Overexpression of circ SMARCA5 inhibits proliferation and invasion of cervical cancer cells while promoting apoptosis, ultimately inhibiting metastasis.

CELL TRANSPLANTATION (2021)

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Review Cell Biology