Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway

Article Biochemistry & Molecular Biology

LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis

Xiaohui Pan et al.

Summary: The increased expression of long noncoding RNA HCG18 in osteosarcoma promotes cell proliferation by regulating the miR-365a-3p/PGK1 axis, enhancing aerobic glycolysis.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA HOXA11 antisense RNA upregulates spermatogenesis-associated serine-rich 2-like to enhance cisplatin resistance in laryngeal squamous cell carcinoma by suppressing microRNA-518a

Na Shen et al.

Summary: This study found that the long noncoding RNA HOXA11-AS can enhance cisplatin resistance in laryngeal squamous cell carcinoma (LSCC) through the miR-518a/SPATS2L axis, providing potential therapeutic strategies for cisplatin-resistant LSCC.

BIOENGINEERED (2022)

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Article Oncology

Identification of TRPV4 as a novel target in invasiveness of colorectal cancer

Peng Zhang et al.

Summary: The study revealed that TRPV4 plays a critical role in colon cancer invasiveness by regulating the EMT process and suppressing AKT activity. The TRPV4-ZEB1 axis was identified as a potential mechanism for tumor metastasis in colon cancer.

BMC CANCER (2021)

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Article Dentistry, Oral Surgery & Medicine

High expression of novel biomarker KRT16P3 promotes the progression of tongue squamous cell carcinoma and predicts poor prognosis

Yifan Yang et al.

Summary: The study showed that KRT16P3 is significantly upregulated in tongue squamous cell carcinoma (TSCC) tissues and is associated with poor prognosis. Knockdown of KRT16P3 was found to inhibit proliferation, migration, and promote apoptosis of TSCC cells, while also suppressing epithelial-mesenchymal transition (EMT) and JAK2/STAT3 signaling pathway.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2021)

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Article Pathology

LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis

Yue Zhu et al.

Summary: The study revealed that HCG18 was down-regulated in PTC, and it suppressed the viability, migration, invasion, and epithelial-mesenchymal transition of PTC cells by regulating the miR-106a-5p/PPP2R2A axis.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Biotechnology & Applied Microbiology

The long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development

Chaoqun Huang et al.

Summary: The study revealed that NORAD enhances the promotive effect of CAFs on GC cells by up-regulating IL-33 and targeting miR-496, providing new insights into the microenvironment of GC cells and CAFs.

BIOENGINEERED (2021)

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Article Oncology

A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

Houyu Ju et al.

Summary: This study identified a novel intronic circular RNA, circGNG7, which acts as a strong tumor suppressor in head and neck squamous cell carcinoma (HNSCC). The circGNG7/HSP27-JNK/P38 MAPK signaling pathway was found to be a novel mechanism by which HNSCC progression can be controlled.

CANCER COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2

Baoshan Ning et al.

Summary: The study revealed that lncRNA CASC9 promotes the malignancy of OSCC cells by sponging miR-545-3p to enhance LAMC2 expression, suggesting a potential intervention approach in OSCC therapy.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA TTN-AS1/microRNA-199a-3p/runt-related transcription factor 1 gene axis regulates the progression of oral squamous cell carcinoma

Zhongzhi Jin et al.

Summary: The study revealed the important roles of TTN-AS1 and RUNX1 in the progression of oral squamous cell carcinoma (OSCC), with miR-199a-3p partially alleviating the effects of TTN-AS1 and RUNX1.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis

Jing Wu et al.

Summary: In this study, it was found that LINC01296 was highly expressed in HNSCC and associated with poor prognosis in patients. Silencing of LINC01296 inhibited tumor cell migration and invasion, possibly participating in the progression of HNSCC through protein phosphorylation and microtubule-based process regulation.

BIOENGINEERED (2021)

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Review Oncology

RNA in cancer

Gregory J. Goodall et al.

Summary: Recent findings have shown that RNA processing is systematically altered in cancer, with mutations in RNA splicing factor genes and the shortening of 3' untranslated regions widely observed. Additionally, evidence suggests that other types of RNAs, including circular RNAs, can contribute to tumorigenesis.

NATURE REVIEWS CANCER (2021)

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Review Genetics & Heredity