Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 21, Issue 6, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.21.6.061006
Keywords
optical coherence tomography; supercontinuum source; biomedical imaging; myocardial imaging; cardiology
Funding
- NIH [1DP2HL127776-01]
- Columbia University Research Initiatives for Science and Engineering (RISE)
- Feldstein Medical Foundation
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D We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72 mu m with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution (5.52 mu m) was compromised to enhance the image penetration required for myocardial imaging. The noise of the SC source was analyzed extensively and an imaging protocol was proposed for SC-based OCT imaging with appreciable contrast. Three-dimensional datasets were acquired ex vivo on the endocardium side of tissue specimens from different chambers of fresh human and swine hearts. With the increased resolution and contrast, features such as elastic fibers, Purkinje fibers, and collagen fiber bundles were observed. The correlation between the structural information revealed in the OCT images and tissue pathology was discussed as well. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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