Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/app12094510
Keywords
Streptomyces sp; butenolide; GNPS; anti-inflammatory activity
Categories
Funding
- Yeungnam University
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2021R1A2C101727, 2020R1A6A1A03044512, 2022R1A2C1004096]
- National Research Foundation of Korea [2022R1A2C1004096] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, seven butenolide compounds were discovered and isolated, and their structures were determined. Compounds 1-6 showed potential anti-inflammatory activities.
Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1-7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1-7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1-6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.
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