Buildup Factor Computation and Percentage Depth Dose Simulation of Tissue Mimicking Materials for an External Photon Beam (0.15-15 MeV)

Nowadays, the use of tissue mimicking material (TMM) is widespread in both diagnostic and therapeutic medicine, as well as for quality assurance and control. For example, patient exposure evaluation during therapeutic tests has been commonly measured using TMMs. However, only a few materials have been developed for research use at the megavoltage photon energy encountered in medical radiology. In this paper, we extended our previous work to cover the photon energy range of 0.15-15 MeV for five human tissues (adipose, cortical bone, fat, lung and muscle). As a selection criterion for TMM, other than the attenuation coefficient, we introduced the computation of the buildup factor (BUF) for a given couple of energy and depth based on the geometric progression fitting method. Hence, we developed a C++ program able to compute BUF for depths up to 40 mean free path. Moreover, we simulated the percentage depth dose (PDD) of a 6 MV photon beam through each tissue and their equivalent materials using the Geant4 Monte Carlo toolkit (version 10.5). After the comparison of a set of parameters (mass attenuation and mass energy absorption coefficients, BUF, equivalent and effective atomic numbers, electron density, superficial and maximal dose and dose at 10 and 20 cm depths), we found that SB3 (a mixture of epoxy and calcium carbonate) and MS15 (a mixture of epoxy, phenol, polyethylene and aluminum oxide) accurately imitate cortical bone and muscle tissues, respectively. AP6 (a mixture of epoxy, phenol, polyethylene and teflon), glycerol trioleate and LN1 (a mixture of polyurethane and aluminum oxide) are also suitable TMMs for adipose, fat and lung tissues, respectively. Therefore, this work can be useful to physician researchers in dosimetry and radiological diagnosis.

Automated summary

This paper investigates the application of tissue mimicking material (TMM) in the field of medical radiology. By calculating the buildup factor (BUF) and simulating the percentage depth dose (PDD), several TMMs that accurately mimic different human tissues were identified. This study is of importance for physicians and researchers in the field of dosimetry and radiological diagnosis.