4.5 Article

Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

Journal

JOURNAL OF BIOMEDICAL OPTICS
Volume 21, Issue 8, Pages -

Publisher

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.21.8.081208

Keywords

hyaluronic acid; optical clearing agents; skin; optoacoustic (photoacoustic) imaging

Funding

  1. National Cancer Institute [R01CA167446]
  2. Seno Medical Instruments (San Antonio, Texas)

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Enhanced delivery of optical clearing agents (OCA) through skin may improve sensitivity of optical and optoacoustic (OA) methods of imaging, sensing, and monitoring. This report describes a two-step method for enhancement of light penetration through skin. Here, we demonstrate that topical application of hyaluronic acid (HA) improves skin penetration of hydrophilic and lipophilic OCA and thus enhances their performance. We examined the OC effect of 100% polyethylene and polypropylene glycols (PPGs) and their mixture after pretreatment by HA, and demonstrated significant increase in efficiency of light penetration through skin. Increased light transmission resulted in a significant increase of OA image contrast in vitro. Topical pretreatment of skin for about 30 min with 0.5% HA in aqueous solution offers effective delivery of low molecular weight OCA such as a mixture of PPG-425 and polyethylene glycol (PEG)-400. The developed approach of pretreatment by HA prior to application of clearing agents (PEG and PPG) resulted in a similar to 47-fold increase in transmission of red and near-infrared light and significantly enhanced contrast of OA images. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

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