4.5 Article

Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis

Journal

JOURNAL OF BIOMEDICAL OPTICS
Volume 21, Issue 9, Pages -

Publisher

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.21.9.095001

Keywords

optical coherence tomography; multiple sclerosis; retinal layers; retinal thicknesses

Funding

  1. National Institutes of Health [NIBIB R01 EB013723]

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We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

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