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Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

STEM CELL REPORTS (2022)

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TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different nonmalignant disorders

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Summary: The study confirms that TCRab/CD19-depleted haploidentical HSCT from an HLA-partially matched relative is an effective treatment for children with NMDs. Prompt donor availability, low incidence of acute GVHD, and TRM make this strategy an attractive option for NMDs patients.

BLOOD ADVANCES (2022)

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Letter Cell & Tissue Engineering

NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Pietro Merli et al.

STEM CELL REPORTS (2022)

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Article Cell & Tissue Engineering

Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma

Lorena Lobo de Figueiredo-Pontes et al.

Summary: Research showed that donor natural killer (NK) cells negatively affect the frequency and function of hematopoietic stem cells (HSC), with interferon-gamma (IFNg) identified as a potential mediator. Improved HSC fitness was achieved by depleting NK cells or blocking IFNg activity from donor infusions.

STEM CELL REPORTS (2021)

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Article Hematology

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Franco Locatelli et al.

BLOOD (2017)

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Article Hematology

Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia

Peter Lang et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

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Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Related references

TCRαβ/CD19 depleted HSCT from an HLA-haploidentical relative to treat children with different nonmalignant disorders

NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia

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