Journal
CANCER PREVENTION RESEARCH
Volume 8, Issue 9, Pages 762-764Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1940-6207.CAPR-15-0229
Keywords
-
Categories
Funding
- NCI NIH HHS [P30 CA014195, R01 CA180175] Funding Source: Medline
Ask authors/readers for more resources
Tomasetti and Vogelstein (1) argue that lifetime cancer risk for particular tissues is mostly determined by the total number of stem cell (SC) divisions within the tissue, whereby most cancers arise due to bad luck-mutations occurring during DNA replication. We argue that the poorly substantiated estimations of SC division parameters and assumptions that oversimplify somatic evolution prevent such a conclusion from being drawn. (C) 2015 AACR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
