Journal
NANOMATERIALS
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nano12101645
Keywords
quantum dots; transition metal dichalcogenide; bio-imaging; density functional theory; quantum confinement
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2019R1A6A1A03032988]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2020R1I1A3071628]
- UNDERGROUND CITY OF THE FUTURE program - Ministry of Science and ICT
- Regional Innovation Strategy (RIS) through the National Research Foundation of Korea (NRF) - Ministry of Education (MOE) [2021RIS-004]
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In this study, the bio-imaging characteristics of water-soluble MoS2 quantum dots were investigated. It was found that the synthesized metallic MoS2 quantum dots exhibited bright luminescence and low toxicity, making them promising for high-performance bio-imaging probes.
Transition metal dichalcogenide-based quantum dots are promising materials for applications in diverse fields, such as sensors, electronics, catalysis, and biomedicine, because of their outstanding physicochemical properties. In this study, we propose bio-imaging characteristics through utilizing water-soluble MoS2 quantum dots (MoS2-QDs) with two different sizes (i.e., similar to 5 and similar to 10 nm). The structural and optical properties of the fabricated metallic phase MoS2-QDs (m-MoS2-QDs) were characterized by transmission electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, UV-vis absorption spectroscopy, and photoluminescence. The synthesized m-MoS2-QDs showed clear photophysical characteristic peaks derived from the quantum confinement effect and defect sites, such as oxygen functional groups. When the diameter of the synthesized m-MoS2-QD was decreased, the emission peak was blue-shifted from 436 to 486 nm under excitation by a He-Cd laser (325 nm). Density functional theory calculations confirmed that the size decrease of m-MoS2-QDs led to an increase in the bandgap because of quantum confinement effects. In addition, when incorporated into the bio-imaging of HeLa cells, m-MoS2-QDs were quite biocompatible with bright luminescence and exhibited low toxicity. Our results are commercially applicable for achieving high-performance bio-imaging probes.
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