RGD Peptide Modified Erythrocyte Membrane/Porous Nanoparticles Loading Mir-137 for NIR-Stimulated Theranostics of Glioblastomas

Article Chemistry, Multidisciplinary

Virus-Mimicking Cell Membrane-Coated Nanoparticles for Cytosolic Delivery of mRNA

Joon Ho Park et al.

Summary: Creating biomimetic nanoparticles capable of mimicking viruses in achieving endosomal escape, allowing successful delivery of payloads to the cytosol of target cells for protein expression.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Oncology

Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Zeenat Mirza et al.

Summary: Breast cancer is one of the deadliest cancers in females, and traditional treatment methods often fall short due to various limitations. Nanoparticles have the potential to revolutionize breast cancer gene therapy by improving circulation time, enhancing bioavailability, reducing immune system recognition, and accurately delivering gene regulators. Their targeted drug delivery mechanisms and advancements in therapeutic strategies show promise for future treatments of breast cancer.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Cell Biology

Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development

Bernarda Majc et al.

Summary: Glioblastoma, the most common brain malignant tumor in adults, poses challenges for effective immunotherapy due to its intracranial location, tumor heterogeneity, and immunosuppressive microenvironment. Various promising immunotherapeutic strategies, such as vaccines, oncolytic viruses, immune checkpoint inhibitors, and adoptive cell transfer, have been applied in an attempt to promote tumor eradication and overcome immune resistance. However, discrepancies exist between preclinical studies and clinical studies in evaluating the efficiency of these strategies on glioblastoma patients.

CELLS (2021)

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Review Oncology

Glioblastoma and MiRNAs

Swalih P. Ahmed et al.

Summary: Glioblastoma (GB) is a lethal brain tumor with limited treatment options and poor prognosis. The use of miRNA in GB diagnosis and treatment is being explored, but further research is needed to understand its relationship with glioblastoma.

CANCERS (2021)

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Article Engineering, Environmental

Biomimetic light-activatable graphene-based nanoarchitecture for synergistic chemophotothermal therapy

Xinyu Cui et al.

Summary: This study successfully constructed a nanodrug carrier with high loading rate via lipid self-assembly, enabling synergistic chemophotothermal therapy for efficient solid tumor removal in vivo. The excellent integration of mesoporous-silica-coated rGO and lipid bilayer demonstrated great potential for graphene-based nanomaterials in biomedical applications.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Red blood cell membrane-coated biomimetic upconversion nanoarchitectures for synergistic chemo-photodynamic therapy

Minghui Li et al.

Summary: Cell-derived nanomaterials, such as the RBC membrane camouflaged core-shell upconversion/mesoporous silica nanoparticles, have excellent biocompatibility, immune escaping capabilities, and multicolor emission. Utilizing a synergistic chemophotodynamic therapy approach, this platform efficiently inhibits tumor growth in vivo.

NEW JOURNAL OF CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Neurosciences