Journal
MULTIPLE SCLEROSIS AND RELATED DISORDERS
Volume 60, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2022.103745
Keywords
Pediatric Onset Multiple Sclerosis; Myelin Oligodendrocyte Glycoprotein-Associated Disorders; Neuromyelitis Optica Spectrum Disorder; Optical Coherence Tomography; Retinal Nerve Fibre Layer; Ganglion Cell Inner Plexiform Layer; Moderate to Vigorous Physical Activity
Categories
Funding
- Foundation of the Consortium of Multiple Sclerosis Centers' MS Workforce of the Future program
- Stem Cell Network
- Ontario Institute for Regenerative Medicine
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MVPA participation is associated with higher RNFL and GCIPL thickness across neuro-inflammatory disorders.
Background: Higher levels of moderate to vigorous physical activity (MVPA) associate with disease activity in pediatric multiple sclerosis (MS). Further, measures of retinal integrity associate with lower brain atrophy, yet the relationship of retinal integrity with MVPA has not been investigated. Objective: To determine the relationship between MVPA and retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness in patients with MS, myelin oligodendrocyte glycoprotein-associated disorders (MOGAD), neuromyelitis optica spectrum disorder (NMOSD), and monophasic acquired demyelin-ating syndromes (monoADS). Methods: 150 consecutive children & LE;18 y.o with neuroinflammatory disorders were included. Outcomes included the Godin Leisure Time Activity Questionnaire (GLTEQ) modeled as both a continuous and categorical variable (any vs no MVPA/Strenuous activity), and RNFL and GCIPL using linear mixed models (JASP 0.14.1). Results: An association was identified between MVPA with RNFL thickness (F (1,133) = 8.40, p = .004) and GCIPL thickness (F(1, 131) = 7.68, p = .006). In the MS cohort, any strenuous physical activity was associated with greater RNFL (F(1,35) = 7.30, p = .011) and GCIPL thickness (F(1,35) = 8.73, p =.006). Conclusions: Any MVPA participation is associated with higher RNFL and GCIPL thickness across neuro-inflammatory disorders.
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