4.7 Article

Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Skeletal muscle derived Musclin protects the heart during pathological overload

Malgorzata Szaroszyk et al.

Summary: This study investigated the role of a muscle hormone called Musclin in heart failure. The results showed that decreased expression of Musclin in muscle exacerbates cardiac dysfunction and myocardial fibrosis, while its overexpression in muscle attenuates these symptoms. Mechanistically, Musclin enhances the levels of C-type natriuretic peptide (CNP), which promotes cardiomyocyte contractility through different signaling pathways and inhibits fibroblast activation. Additionally, reduced expression of OSTN, the gene encoding Musclin, was found in skeletal muscle of heart failure patients, suggesting that increasing Musclin levels could be a potential therapeutic strategy.

NATURE COMMUNICATIONS (2022)

Article Endocrinology & Metabolism

Serum microRNA-486-5p expression in obese Egyptian children and its possible association with fatty liver

Mahmoud A. Al Azzouny et al.

Summary: The study demonstrated that the miR-486-5p gene is up-regulated in obese children and is associated with the development of obesity and fatty liver. Expression of the miR-486-5p gene correlates positively with weight, BMI, fat mass, and other indicators.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Article Biochemistry & Molecular Biology

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets

Damian Szklarczyk et al.

Summary: The STRING database integrates various associations between proteins, including physical interactions and functional associations, by collecting evidence from sources such as literature, databases, computational predictions, and systematic transfers. STRING aims for wide coverage and provides extensive user interface features and querying methods for experimental data.

NUCLEIC ACIDS RESEARCH (2021)

Review Cell Biology

Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Samuel Darkwah et al.

Summary: EVs play a key role in intercellular communication, with muscle cell-derived EVs potentially modulating organ remodeling by carrying myokines and other substances, contributing to the establishment and modulation of pre-metastatic niches in vital sites for metastatic tumors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Endocrinology & Metabolism

Hormonally Regulated Myogenic miR-486 Influences Sex-specific Differences in Cancer-induced Skeletal Muscle Defects

Ruizhong Wang et al.

Summary: Male patients exhibit more severe cancer-induced skeletal muscle damage compared to female patients, and hormones and sex chromosomal differences may play a role in this gender difference. The myogenic microRNA miR-486 has been identified as a marker of sex-specific differences in cancer-induced skeletal muscle defects, suggesting its involvement in mitigating muscle damage through regulating myoblast function.

ENDOCRINOLOGY (2021)

Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Endocrinology & Metabolism

Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients

Mohamed Bakr Zaki et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2019)

Article Cell Biology

Modeling Human Cancer-induced Cachexia

Erin E. Talbert et al.

CELL REPORTS (2019)

Review Medicine, Research & Experimental

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

Silvia Lorente-Cebrian et al.

CLINICAL SCIENCE (2019)

Review Cell Biology

Diversification of the muscle proteome through alternative splicing

Kiran Nakka et al.

SKELETAL MUSCLE (2018)

Article Medicine, General & Internal

Cancer-associated cachexia

Vickie E. Baracos et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Review Cell & Tissue Engineering

Humanizing the mdx mouse model of DMD: the long and the short of it

Nora Yucel et al.

NPJ REGENERATIVE MEDICINE (2018)

Article Biochemistry & Molecular Biology

Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength

Serge Summermatter et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Article Nutrition & Dietetics

Abnormal carbohydrate metabolism in a canine model for muscular dystrophy

Andressa R. Amaral et al.

JOURNAL OF NUTRITIONAL SCIENCE (2017)

Review Cell Biology

Mechanisms of metabolic dysfunction in cancer-associated cachexia

Michele Petruzzelli et al.

GENES & DEVELOPMENT (2016)

Article Biochemistry & Molecular Biology

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

Steven A. Bullard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function

Malik M. Keshwani et al.

BIOCHEMICAL JOURNAL (2015)

Article Multidisciplinary Sciences

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

Yetrib Hathout et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Editorial Material Medicine, General & Internal

IL-6 Blockade as a Therapeutic Approach for Duchenne Muscular Dystrophy

Andrew L. Mammen et al.

EBIOMEDICINE (2015)

Review Cell Biology

Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis

Margaret Buckingham et al.

DEVELOPMENTAL CELL (2014)

Article Biochemistry & Molecular Biology

P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism

Erin R. Wissing et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Myostatin signaling regulates Akt activity via the regulation of miR-486 expression

Keisuke Hitachi et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Medicine, Research & Experimental

MicroRNA-486 dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms

Matthew S. Alexander et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Cancer cachexia decreases specific force and accelerates fatigue in limb muscle

B. M. Roberts et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Endocrinology & Metabolism

Changes in Circulating MicroRNAs Are Associated With Childhood Obesity

Anna Prats-Puig et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Cell Biology

Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic target

Clara Crescioli et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Kinase Consensus Sequences: A Breeding Ground for Crosstalk

Heather L. Rust et al.

ACS CHEMICAL BIOLOGY (2011)

Article Multidisciplinary Sciences

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

Mattia Boeri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Regulation of DMD pathology by an ankyrin-encoded miRNA

Matthew S. Alexander et al.

SKELETAL MUSCLE (2011)

Article Oncology

Long-term Prognostic Role of Functional Limitations Among Women With Breast Cancer

Dejana Braithwaite et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Article Clinical Neurology

ALTERED MEF2 ISOFORMS IN MYOTONIC DYSTROPHY AND OTHER NEUROMUSCULAR DISORDERS

Linda L. Bachinski et al.

MUSCLE & NERVE (2010)

Article Multidisciplinary Sciences

Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486

Eric M. Small et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients

Masami Tanaka et al.

PLOS ONE (2009)

Article Biochemistry & Molecular Biology

Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy

Joseph G. Reynolds et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Genetics & Heredity

HMGN1 is dispensable for myogenesis and adipogenesis

DA Hill et al.

Article Medicine, Research & Experimental

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

J Altomonte et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)