Novel insights into the interaction between N6-methyladenosine modification and circular RNA

As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. In this review, we summarize the characteristics and biological functions of m(6)A and circRNAs and focus on recent advances in the interaction of m(6)A modification and circRNAs. In addition, the potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are discussed.

Automated summary

In this review, the characteristics, biological functions, and interaction between N6-methyladenosine (m(6)A) modification and circular RNAs (circRNAs) are summarized. Extensive studies have shown that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Additionally, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. The potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are also discussed.