Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Review Critical Care Medicine

Six-Minute Walk Distance After Critical Illness: A Systematic Review and Meta-Analysis

Selina M. Parry et al.

Summary: The study findings suggest a significant improvement in 6MWD at 12 months compared to 3 months post discharge. Factors such as female sex, preexisting comorbidity, and ARDS are associated with lower 6MWT results.

JOURNAL OF INTENSIVE CARE MEDICINE (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Attributes and predictors of long COVID

Carole H. Sudre et al.

Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Immunology

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Ryan S. Thwaites et al.

Summary: The study found that levels of inflammatory cytokines and chemokines gradually increased with the severity of COVID-19, with IL-6 and GM-CSF playing central roles in the pathogenesis of the disease. Comparisons with samples from fatal influenza patients revealed that GM-CSF was prominent only in COVID-19, further identifying key factors that characterize and distinguish severe and fatal COVID-19.

SCIENCE IMMUNOLOGY (2021)

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Article Critical Care Medicine

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Rachael A. Evans et al.

Summary: The study aimed to understand the impact of COVID-19-related hospitalization on health and employment, identify factors associated with recovery, and describe recovery phenotypes. Findings revealed that some patients did not fully recover six months after discharge, with factors such as female sex, middle age, comorbidities, and severe illness contributing to difficulties in recovery. The study also identified four different recovery phenotypes.

LANCET RESPIRATORY MEDICINE (2021)

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Article Respiratory System

Prevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study

Cesar Fernandez-de-las-Penas et al.

Summary: This study investigated the prevalence of post-COVID-19 cough one year after hospital discharge in COVID-19 survivors and found that a significant proportion of patients still experienced respiratory symptoms post-discharge, with a 2.5% prevalence of long-term cough. No clear risk factors associated with long-term post-COVID-19 cough were identified.

LUNG (2021)

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Article Critical Care Medicine

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Annemarie Docherty et al.

Summary: The reduction in in-hospital mortality of COVID-19 patients during the first wave in the UK was partially attributed to changes in case-mix and illness severity, as well as changes in respiratory support and steroid treatment. Unexplained improvement in in-hospital mortality could be associated with changes in community behavior, inoculum dose, and hospital capacity strain.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, General & Internal

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

Lixue Huang et al.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Evdoxia Kyriazopoulou et al.

Summary: The SAVE-MORE phase 3 study demonstrated the efficacy of anakinra, an IL-1 alpha/beta inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, showing significant reduction in clinical deterioration and decreased 28-day mortality.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Long COVID in a prospective cohort of home-isolated patients

Bjorn Blomberg et al.

Summary: An analysis of patients with SARS-CoV-2 infections in Bergen, Norway, revealed that a high proportion of patients experienced long-term COVID symptoms at 6 months, even though they were relatively young and had only mild to moderate acute COVID-19 symptoms. This highlights the significance of infection control measures, such as vaccination.

NATURE MEDICINE (2021)

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Editorial Material Otorhinolaryngology

Sequelae in adults at 12 months after mild-to-moderate coronavirus disease 2019 (COVID-19)

Paolo Boscolo-Rizzo et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2021)

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Article Immunology

Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics

Krzysztof Laudanski et al.

Summary: The study identified increased expression of several chemokines in COVID-19 patients early in the course of the disease, with older age positively correlating with certain immune markers and pre-existing conditions positively correlating with others. Treatment with various medications had limited effects on the serum variation of biomarkers, highlighting potential targets related to COVID-19 heterogeneity.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Long-Term Elevated Inflammatory Protein Levels in Asymptomatic SARS-CoV-2 Infected Individuals

Liina Tserel et al.

Summary: In a study of SARS-CoV-2 antibody-positive individuals conducted 7-8 months post-infection, it was found that antibodies to the N protein declined while antibodies to the S-RBD remained stable. The antibodies to S-RBD were correlated with viral neutralization capacity and CD4(+) T cell responses. Additionally, asymptomatic antibody-positive individuals showed increased serum levels of markers associated with activated macrophages-monocytes, indicating long-term persistent inflammatory effects of the viral infection.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Long-Term Outcomes of Patients with Coronavirus Disease 2019 at One Year after Hospital Discharge

Modesto M. Maestre-Muniz et al.

Summary: The study investigated post-acute health consequences and mortality one year after hospital discharge among survivors of acute COVID-19. The findings revealed a 7.5% mortality rate among survivors and a significant proportion experiencing ongoing symptoms 1 year after disease onset.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Treatment Guidelines for PTSD: A Systematic Review

Alicia Martin et al.

Summary: Most international treatment guidelines for post-traumatic stress disorder recommend both psychological and pharmacological therapies as first-line treatments, with cognitive behavioural therapy and selective serotonin reuptake inhibitors being the most recommended. However, targeted treatment of nightmares as a symptom of PTSD is not adequately addressed in most guidelines.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Respiratory System