Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 104, Issue 10, Pages 2456-2465Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.35783
Keywords
arabinoxylan; silver dressing; wound healing; Kirby-Bauer disk diffusion susceptibility test; polysaccharide
Funding
- National Science Foundation (CAREER award) [CBET0954957]
- National Institutes of Health [R01EY024072]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0954957] Funding Source: National Science Foundation
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Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456-2465, 2016.
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