Journal
JOURNAL OF IMMUNOLOGY RESEARCH
Volume 2022, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2022/5412007
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Funding
- Guangxi Natural Science Foundation [2020GXNSFAA259050]
- Guangxi Zhuang Autonomous Region Healthy Committee [Z20190749]
- Youjiang Medical University for Nationalities Research Project [yy2019bsky001]
- Guangxi Medical High-level Leading Talents Training '139' Project
- special funding for Guangxi Special Experts [GRCT[2019]13]
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In this study, three endothelial cell subclusters were identified in the tumor microenvironment, and their roles in metastasis were revealed. This has important implications for inhibiting triple-negative breast cancer metastasis.
Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow cytometry and bioinformatic analysis to identify three endothelial cell subclusters: EC (ATP1B3), EC (HSPA1B), and EC (KRT7) in the tumor microenvironment. These endothelial cell subclusters exhibited distinguishing biological features. Based on differentially expressed genes derived from the subclusters, gene set enrichment analysis showed that EC (ATP1B3) and EC (HSPA1B) contribute to the process of metastasis, for example, in fibrosarcoma and anaplastic carcinoma. In this study, we identified the heterogeneity of endothelial cells in the human breast cancer and have provided insights into its role in metastasis.
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