The health benefits of selenium in food animals: a review

Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and humans. It evinces a strong antioxidant, anti-inflammatory and potential antimicrobial capacity. Selenium biological function is primarily achieved by its presence in selenoproteins as a form of selenocysteine. Selenium deficiency may result in an array of health disorders, affecting many organs and systems; to prevent this, dietary supplementation, mainly in the forms of organic (i.e., selenomethionine and selenocysteine) inorganic (i.e., selenate and selenite) sources is used. In pigs as well as other food animals, dietary selenium supplementation has been used for improving growth performance, immune function, and meat quality. A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative damage. Selenium also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral replication. In this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation, its antioxidant and immunomodulatory actions, and the putative antimicrobial effect thereof. Furthermore, our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral, underscoring the need for further in vivo and in vitro studies, particularly in pigs.

Automated summary

Selenium is an essential trace mineral with strong antioxidant, anti-inflammatory, and potential antimicrobial capacities. It is primarily present in selenoproteins as selenocysteine, playing a crucial role in maintaining homeostasis. Dietary selenium supplementation, in both organic and inorganic forms, improves growth performance, immune function, and meat quality in food animals like pigs. Additionally, selenium exhibits antiviral activity by protecting immune cells and inhibiting viral replication. However, further in vivo and in vitro studies are needed to explore the full potential of selenium as an antiviral agent.