Journal
GENES
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/genes13050897
Keywords
multiple sclerosis; Interleukin 6; SNPs; CSF; neuroinflammation
Categories
Funding
- FISM grants (Fondazione Italiana Sclerosi Multipla) [2019/S/1]
- FISM-Fondazione Italiana Sclerosi Multipla [2020/R-Multi/018]
- Progetto di Rete [RCR-2020-23670067]
- Progetto Nuovi biomarker diagnostici e terapeutici delle malattie neurodegenerative
- FISM [2020/BS/003]
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This study found an association between the rs1818879 polymorphism in the IL-6 gene and subclinical neuroinflammatory activity in RR-MS patients, suggesting that interindividual differences in the IL-6 gene may influence the immune activation profile in MS.
(1) Background: The clinical course of multiple sclerosis (MS) is critically influenced by the expression of different pro-inflammatory and anti-inflammatory cytokines. Interleukin 6 (IL-6) represents a major inflammatory molecule previously associated with exacerbated disease activity in relapsing remitting MS (RR-MS); however, the role of single-nucleotide polymorphisms (SNPs) in the IL-6 gene has not been fully elucidated in MS. (2) Methods: We explored in a cohort of 171 RR-MS patients, at the time of diagnosis, the associations between four IL-6 SNPs (rs1818879, rs1554606, rs1800797, and rs1474347), CSF inflammation, and clinical presentation. (3) Results: Using principal component analysis and logistic regression analysis we identified an association between rs1818879, radiological activity, and a set of cytokines, including the IL-1 beta, IL-9, IL-10, and IL-13. No significant associations were found between other SNPs and clinical or inflammatory parameters. (4) Conclusions: The association between the rs1818879 polymorphism and subclinical neuroinflammatory activity suggests that interindividual differences in the IL-6 gene might influence the immune activation profile in MS.
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