Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease

Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.

Automated summary

This article discusses the importance of chromatin organization in maintaining gene expression regulation and cell identity, as well as the causes and mechanisms of chromatin disorganization during cell division. Additionally, it highlights the impact of these chromatin alterations on gene expression control and diseases related to cell proliferation.