Journal
GENES
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/genes13050749
Keywords
long-lived families; circular RNA; co-expression; healthy aging
Categories
Funding
- National Key R&D Program of China [2018YFC2000400, 2018YFE0203700]
- Key Research Program [KFZD-SW-221]
- Strategic Priority Research Program [XDPB17]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences, National Natural Science Foundation of China [82071595]
- Yunnan Applied Basic Research Project [202101AS070058, 202101AT070299, . 2019FB094, 202101AS070314]
- Yunling Scholar of Yunnan Province, and Science and Technology Leading Talent Program of the Spring City (Kunming)
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Deep RNA sequencing of blood samples from long-lived families revealed that circRNA expression in long-lived elderly individuals does not follow an age-accumulating pattern. Weighted co-expression network analysis identified circRNA modules associated with healthy aging pathways.
Deep RNA sequencing of 164 blood samples collected from long-lived families was performed to investigate the expression patterns of circular RNAs (circRNAs). Unlike that observed in previous studies, circRNA expression in long-lived elderly individuals (98.3 +/- 3.4 year) did not exhibit an age-accumulating pattern. Based on weighted circRNA co-expression network analysis, we found that longevous elders specifically gained eight but lost seven conserved circRNA-circRNA co-expression modules (c-CCMs) compared with normal elder controls (spouses of offspring of long-lived individuals, age = 59.3 +/- 5.8 year). Further analysis showed that these modules were associated with healthy aging-related pathways. These results together suggest an important role of circRNAs in regulating human lifespan extension.
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