Graph Theory Analysis of the Cortical Functional Network During Sleep in Patients With Depression

Depression, a common mental illness that seriously affects the psychological health of patients, is also thought to be associated with abnormal brain functional connectivity. This study aimed to explore the differences in the sleep-state functional network topology in depressed patients. A total of 25 healthy participants and 26 depressed patients underwent overnight 16-channel electroencephalography (EEG) examination. The cortical networks were constructed by using functional connectivity metrics of participants based on the weighted phase lag index (WPLI) between the EEG signals. The results indicated that depressed patients exhibited higher global efficiency and node strength than healthy participants. Furthermore, the depressed group indicated right-lateralization in the delta band. The top 30% of connectivity in both groups were shown in undirected connectivity graphs, revealing the distinct link patterns between the depressed and control groups. Links between the hemispheres were noted in the patient group, while the links in the control group were only observed within each hemisphere, and there were many long-range links inside the hemisphere. The altered sleep-state functional network topology in depressed patients may provide clues for a better understanding of the depression pathology. Overall, functional network topology may become a powerful tool for the diagnosis of depression.

Automated summary

Depressed patients exhibit differences in sleep-state functional network topology, including increased global efficiency and node strength, as well as right-lateralization in the delta band. The connectivity patterns between depressed patients and healthy controls are distinct, with depressed patients showing inter-hemispheric connections while healthy controls showing only intra-hemispheric connections. These findings provide insights into the pathology of depression and suggest that functional network topology could be a potential tool for diagnosing depression.