Journal
JOURNAL OF BIOMECHANICS
Volume 49, Issue 12, Pages 2502-2512Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2016.02.041
Keywords
Aortic valve; Fluid structure interaction; Arbitrary Lagrangian Eulerian; Anisotropic material model
Categories
Funding
- Marie Curie EST Fellowship [MEST/CT/2005/020327]
- Leeds Center of Excellence in Medical Engineering - Wellcome Trust
- Engineering and Physical Sciences Research Council [WT088908/z/09/z]
- Engineering and Physical Sciences Research Council Advanced Research Fellowship [EP/D073618/1]
- Engineering and Physical Sciences Research Council [EP/D073618/1] Funding Source: researchfish
- EPSRC [EP/D073618/1] Funding Source: UKRI
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This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and thickness inhomogeneity were found to significantly affect the valve stress-strain distribution. However, their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and anisotropic nonlinear mechanical properties, to accurately predict the stress-strain distribution on the natural aortic valve. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.
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