4.6 Review

Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

C-Terminal Basic Region of Troponin T Alters the Ca2+-Dependent Changes in Troponin I Interactions

Li Zhu et al.

Summary: The C-terminal 14-16 residues of human troponin T are crucial for full inactivation and prevent full activation at saturating Ca2+. The basic residues within this region are essential for the function of TnT, but the mechanism of action is still unknown.

BIOCHEMISTRY (2022)

Article Biophysics

Troponin Revealed: Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle

Larry S. Tobacman

Summary: Recent advances in understanding the structural basis of troponin-tropomyosin's regulation of striated muscle contraction, particularly through cryo-electron microscopy data, have revealed compelling atomic models for both apo- and Ca2+-saturated states. Subsequent analyses have further elucidated these findings, showing the hindering effects of troponin and tropomyosin on myosin-actin binding in relaxed muscle and the specific bindings in the Ca2+-saturated state.

BIOPHYSICAL JOURNAL (2021)

Article Cell Biology

Troponin structure and function: a view of recent progress

Steven Marston et al.

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2020)

Article Multidisciplinary Sciences

Cardiac muscle thin filament structures reveal calcium regulatory mechanism

Yurika Yamada et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity

Alfredo Jesus Lopez Davila et al.

BIOCHEMISTRY (2020)

Article Physiology

The mechanism of thin filament regulation: Models in conflict?

Michael A. Geeves et al.

JOURNAL OF GENERAL PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy

Cristina Risi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility

Yuanhua Cheng et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Review Cell Biology

The myosin-activated thin filament regulatory state, M - -open: a link to hypertrophic cardiomyopathy (HCM)

Sherwin S. Lehrer et al.

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2014)

Article Biotechnology & Applied Microbiology

Isoform Diversity, Regulation, and Functional Adaptation of Troponin and Calponin

Jian-Ping Jin et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2012)

Review Cell Biology

Disease causing mutations of troponin alter regulated actin state distributions

Joseph M. Chalovich

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2012)

Article Chemistry, Physical

A Computational and Experimental Approach To Investigate Bepridil Binding with Cardiac Troponin

Jayson F. Varughese et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2011)

Article Biochemistry & Molecular Biology

Localization of the two tropomyosin-binding sites of troponin T

J. -P. Jin et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Article Biophysics

Kinetics of Regulated Actin Transitions Measured by Probes on Tropomyosin

Emma Borrego-Diaz et al.

BIOPHYSICAL JOURNAL (2010)

Article Cell Biology

Phosphorylation of Tropomyosin Extends Cooperative Binding of Myosin Beyond a Single Regulatory Unit

Vijay S. Rao et al.

CELL MOTILITY AND THE CYTOSKELETON (2009)

Article Cardiac & Cardiovascular Systems

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Andrew P. Landstrom et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)

Article Biochemistry & Molecular Biology

Maximal activation of skeletal muscle thin filaments requires both rigor myosin S1 and calcium

DH Heeley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Single particle analysis of relaxed and activated muscle thin filaments

A Pirani et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Cardiac & Cardiovascular Systems

Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium

JE Stelzer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy

R Lang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

High-affinity actin-binding nebulin fragments influence the ActoS1 complex

DD Root et al.

BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

D Szczesna et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)