Related references
Note: Only part of the references are listed.Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics
Tom M. Quinn et al.
EBIOMEDICINE (2022)
Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system
Lena Gottesman-Katz et al.
GUT (2021)
Local immune response to food antigens drives meal-induced abdominal pain
Javier Aguilera-Lizarraga et al.
NATURE (2021)
Proteolytic Cleavage of Bioactive Peptides and Protease-Activated Receptors in Acute and Post-Colitis
Michelle De Bruyn et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Pruritogenic mechanisms and gut sensation: putting the irritant into irritable bowel syndrome
Mariana Brizuela et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)
Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats
Nikita Hanning et al.
PHARMACEUTICS (2021)
Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS
Shoko Edogawa et al.
GUT (2020)
The Interplay Between Genetic Risk Factors and Proteolytic Dysregulation in the Pathophysiology of Inflammatory Bowel Disease
Nuria Sola Tapias et al.
JOURNAL OF CROHNS & COLITIS (2020)
Animal Models for Functional Gastrointestinal Disorders
Alison Accarie et al.
FRONTIERS IN PSYCHIATRY (2020)
Bacterial modulation of visceral sensation: mediators and mechanisms
Alan E. Lomax et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Bethany M. Anderson et al.
SCIENTIFIC REPORTS (2019)
Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome
D. Batemans et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)
Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome
Hannah Ceuleers et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distensionproof-of-concept
Adam Fabisiak et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2018)
Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons
Cleo Desormeaux et al.
PAIN (2018)
Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients
Sabine Buhner et al.
PLOS ONE (2018)
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
Marcin Poreba et al.
CHEMICAL SCIENCE (2018)
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Alexandre Denadai-Souza et al.
SCIENTIFIC REPORTS (2018)
A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human beta-Tryptase
Sarah F. Giardina et al.
PHARMACOLOGY (2018)
Epithelial expression and function of trypsin-3 in irritable bowel syndrome
Claire Rolland-Fourcade et al.
GUT (2017)
Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease
Michael D. Mayers et al.
JOURNAL OF PROTEOME RESEARCH (2017)
Regulation of intestinal permeability: The role of proteases
Hanne Van Spaendonk et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2017)
A Bottom-Up Proteomic Approach to Identify Substrate Specificity of Outer-Membrane Protease OmpT
Sarah E. Wood et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity
Dafne Balemans et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome
Mira M. Wouters et al.
GASTROENTEROLOGY (2016)
Protease inhibition as new therapeutic strategy for GI diseases
Nathalie Vergnolle
GUT (2016)
Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome
Wen-Jing Liang et al.
GUT AND LIVER (2016)
Structural changes in gastric glial cells and delayed gastric emptying as responses to early life stress and acute adulthood stress in rats
Kazunari Tominaga et al.
LIFE SCIENCES (2016)
Safety and Tolerability of Nafamostat Mesilate and Heparin as Anticoagulants in Leukocytapheresis for Ulcerative Colitis: Post Hoc Analysis of a Large-Scale, Prospective, Observational Study
Koji Sawada et al.
THERAPEUTIC APHERESIS AND DIALYSIS (2016)
Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity
Mathieu Meleine et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2016)
Expression and physiology of opioid receptors in the gastrointestinal tract
Paula Mosinska et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2016)
The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
Mohammad H. Farzaei et al.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2016)
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome
Nicolas Cenac et al.
GASTROENTEROLOGY (2015)
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain
Peishen Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndrome
Marta Zielinska et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)
Sensitisation of TRPV4 by PAR(2) is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase
Silvia Sostegni et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci
Luis G. Bermudez-Humaran et al.
MICROBIAL CELL FACTORIES (2015)
Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit
David Tooth et al.
GUT (2014)
Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4
Peishen Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors
Tsukasa Nozu et al.
JOURNAL OF GASTROENTEROLOGY (2014)
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling
Paulina Kasperkiewicz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Biased signaling of protease-activated receptors
Peishen Zhao et al.
FRONTIERS IN ENDOCRINOLOGY (2014)
A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats
Lara Moussa et al.
CLINICAL NUTRITION (2013)
Protease-Activated Receptors as Therapeutic Targets in Visceral Pain
Nicolas Cenac
CURRENT NEUROPHARMACOLOGY (2013)
Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress
Brent Myers et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)
The Expression of Protease-Activated Receptor 2 and 4 in the Colon of Irritable Bowel Syndrome Patients
Ju-hui Zhao et al.
DIGESTIVE DISEASES AND SCIENCES (2012)
Bacterial proteases in IBD and IBS
Natalie Steck et al.
GUT (2012)
Global identification of peptidase specificity by multiplex substrate profiling
Anthony J. O'Donoghue et al.
NATURE METHODS (2012)
Peripheral a-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats
R. M. van den Wijngaard et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2012)
Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain
A. Annahazi et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2012)
Activity of protease-activated receptors in primary cultured human myenteric neurons
Eva M. Kugler et al.
FRONTIERS IN NEUROSCIENCE (2012)
Met-enkephalins in patients with inflammatory bowel diseases
D. Owczarek et al.
ADVANCES IN MEDICAL SCIENCES (2011)
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity
Siobhain M. O'Mahony et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
A protease inhibitor against acute stress-induced visceral hypersensitivity and paracellular permeability in rats
Juhui Zhao et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Activity of Protease-Activated Receptors in the Human Submucous Plexus
Kerstin Mueller et al.
GASTROENTEROLOGY (2011)
Intestinal Tissue Kallikrein-Kinin System in Inflammatory Bowel Disease
Antoni Stadnicki
INFLAMMATORY BOWEL DISEASES (2011)
Identification of Calpain Substrates by ORF Phage Display
Nora B. Caberoy et al.
MOLECULES (2011)
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice
Fiore Cattaruzza et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)
Emerging principles in protease-based drug discovery
Marcin Drag et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain
H. Eutamene et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2010)
A Focus Group Assessment of Patient Perspectives on Irritable Bowel Syndrome and Illness Severity
Douglas A. Drossman et al.
DIGESTIVE DISEASES AND SCIENCES (2009)
Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome
Sabine Buhner et al.
GASTROENTEROLOGY (2009)
Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses
P. A. Hughes et al.
GUT (2009)
Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression
Ben Ryan et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2009)
Unbalanced expression of protease-activated receptors-1 and-2 in the colon of diarrhea-predominant irritable bowel syndrome patients
Zhao Xiang Bian et al.
JOURNAL OF GASTROENTEROLOGY (2009)
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways
Laurence Martin et al.
PAIN (2009)
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice
Anita Annahazi et al.
PAIN (2009)
Excitation and sensitization of nociceptors by bradykinin: what do we know?
Kazue Mizumura et al.
EXPERIMENTAL BRAIN RESEARCH (2009)
A method for quantifying the unstable and highly polar drug nafamostat mesilate in human plasma with optimized solid-phase extraction and ESI-MS detection: more accurate evaluation for pharmacokinetic study
Yan-guang Cao et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)
Bowman-birk inhibitor concentrate: A novel therapeutic agent for patients with active ulcerative colitis
Gary R. Lichtenstein et al.
DIGESTIVE DISEASES AND SCIENCES (2008)
Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties
Jurgen Joossens et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
Andrew D. Grant et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Peripheral and central mechanisms of visceral sensitization in man
P. Anand et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2007)
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cε- and A-dependent mechanisms in rats and mice
Silvia Amadesi et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model
Birgit Adam et al.
PAIN (2006)
Targeting proteases: successes, failures and future prospects
Boris Turk
NATURE REVIEWS DRUG DISCOVERY (2006)
Filamentous phage display in the new millennium
JW Kehoe et al.
CHEMICAL REVIEWS (2005)
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
S Bradesi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
G Barbara et al.
GASTROENTEROLOGY (2004)
Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2
N Kawao et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2004)
Long-term effects of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension
JM Gschossmann et al.
DIGESTIVE DISEASES AND SCIENCES (2004)
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
Y Dai et al.
JOURNAL OF NEUROSCIENCE (2004)
Human and mouse proteases:: A comparative genomic approach
XS Puente et al.
NATURE REVIEWS GENETICS (2003)
Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat
SV Coutinho et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study
WJ Tremaine et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2002)
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli
S Asfaha et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Share Paper
