New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases

CCR7, collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking. In this review, we take an in-depth look at the structural-functional domains of CCR7 and CCR7-bearing dendritic cell trajectory to lymph nodes. Then, we summarize the regulatory network of CCR7, including transcriptional regulation, translational and posttranslational regulation, internalization, desensitization, and recycling. Furthermore, the potential strategies of targeting the CCR7 network to regulate dendritic cell migration and to deal with inflammatory diseases are integrated, which not only emphasizes the possibility of CCR7 to be a potential target of immunotherapy but also has an implication on the homing of dendritic cells to benefit inflammatory diseases.

Automated summary

CCR7, along with its ligands CCL19 and CCL21, plays a crucial role in controlling migratory events in the immune system. Abnormal expression of CCR7 in dendritic cells can lead to inflammatory diseases due to disrupted dendritic cell trafficking. This review focuses on the structural-functional domains of CCR7 and its impact on dendritic cell migration to lymph nodes, as well as the regulatory network of CCR7. Furthermore, potential strategies targeting the CCR7 network to regulate dendritic cell migration and manage inflammatory diseases are discussed.