Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.838647
Keywords
astragalus polysaccharide; angiogenesis; axonal regeneration; functional recovery; peripheral nerve injury
Categories
Funding
- National Natural Science Foundation of China [82071388]
- Postdoctoral Science Foundation of China [2019M660175]
- Young and middle-aged Health Science and Technology Innovation Talent of Henan Province [YXKC2020048]
- Excellent Youth Science Foundation of Henan Province [212300410077]
- Key Research Project of Henan Educational Committee [21A320033]
Ask authors/readers for more resources
A bioactive Radix Astragalus polysaccharide (RAP) extracted from traditional Chinese medicine (TCM) was found to promote nerve regeneration and angiogenesis, thereby enhancing functional recovery in peripheral nerve injury.
Peripheral nerve injury (PNI) results in loss of neural control and severe disabilities in patients. Promoting functional nerve recovery by accelerating angiogenesis is a promising neuroprotective treatment strategy. Here, we identified a bioactive Radix Astragalus polysaccharide (RAP) extracted from traditional Chinese medicine (TCM) as a potent enhancer of axonal regeneration and remyelination. Notably, RAP promoted functional recovery and delayed gastrocnemius muscle atrophy in a rat model of sciatic nerve crush injury. Further, RAP treatment may induce angiogenesis in vivo. Moreover, our in vitro results showed that RAP promotes endothelial cell (EC) migration and tube formation. Altogether, our results show that RAP can enhance functional recovery by accelerating angiogenesis, which was probably related to the activation of AKT/eNOS signaling pathway, thereby providing a polysaccharide-based therapeutic strategy for PNI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
